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cytotoxic T-lymphocyte-associated protein 4

Summary

Gene Symbol

Ctla4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12477

PubChem

12477

Alliance of Genome Resources

MGI:88556

Annotation

Keyword

3D-structure
Adaptive immunity
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6GTR6	Cytotoxic T-lymphocyte-associated antigen 4
Q5SSM0	Cytotoxic T-lymphocyte-associated antigen 4
P09793	Cytotoxic T-lymphocyte-associated antigen 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
T cell receptor signaling pathway	IBA
negative regulation of T cell proliferation	ISO
regulation of T cell proliferation	IEA
negative regulation of regulatory T cell differentiation	IBA ISO
adaptive immune response	IEA

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

immune response [inference]

adaptive immune response

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of lymphocyte proliferation [inference]

regulation of T cell activation [inference]

regulation of T cell proliferation

negative regulation of T cell proliferation

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

regulation of lymphocyte differentiation [inference]

regulation of T cell differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

regulation of regulatory T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of lymphocyte differentiation [inference]

negative regulation of T cell differentiation [inference]

negative regulation of regulatory T cell differentiation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA IDA ISO	16227984
Golgi apparatus	ISO
plasma membrane	ISO ISS
clathrin-coated endocytic vesicle	ISO
protein complex involved in cell adhesion	ISO	7544393

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cytotoxic T-lymphocyte protein 4

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
B cell receptor signaling pathway
T cell receptor signaling pathway
adaptive immune response
immune response
immune system process
negative regulation of regulatory T cell differentiation
regulation of T cell proliferation

Displaying **all 6** entries
InterPro
Cytotoxic T-lymphocyte antigen 4
Cytotoxic T-lymphocyte protein 4/CD28
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying entries **1 - 10** of 50 in total

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DO ID	Disease Name	Source
DOID:0060025	immunoglobulin alpha deficiency	Alliance of Genome Resources
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080846	latent autoimmune diabetes in adults	Alliance of Genome Resources
DOID:0081120	Graves ophthalmopathy	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:0110751	type 1 diabetes mellitus 12	Alliance of Genome Resources
DOID:10325	silicosis	Alliance of Genome Resources
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:11168	anogenital venereal wart	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1493		HGNC:2505	HUMAN66525
Rattus norvegicus	63835	10116_1:0032b0	RGD:61975	RATNO43208
Bos taurus	281732			BOVIN24619
Sus scrofa	397286			PIGXX09845
Canis lupus familiaris	403696			CANLF14144
Ovis aries	443040			SHEEP09675
Pan troglodytes	470619			PANTR29583
Felis catus	493743			FELCA21569
Macaca mulatta	705673			MACMU06886
Monodelphis domestica	100017900			MONDO31963

GlyTouCan

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