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SPNS lysolipid transporter 2, sphingosine-1-phosphate

Summary

Gene Symbol

SPNS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

124976

PubChem

124976

Alliance of Genome Resources

HGNC:26992

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Endosome
Lipid transport
Non-syndromic deafness
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IVW8	Protein spinster homolog 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
regulation of eye pigmentation	IEA
transmembrane transport	IEA
B cell homeostasis	IEA
regulation of T cell migration	ISS
lipid transport	IBA IDA	21084291

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration

transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

hematopoietic or lymphoid organ development [inference]

lymph node development

bone development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

organic substance transport [inference]

lipid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of immune response [inference]

regulation of humoral immune response

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of response to stimulus [inference]

regulation of immune response [inference]

regulation of humoral immune response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

regulation of eye pigmentation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IBA
plasma membrane	TAS
endosome membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sphingolipid transporter activity	IBA IDA TAS	21084291
transmembrane transporter activity	IBA IEA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

sphingolipid transporter activity

transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111643	autosomal recessive nonsyndromic deafness 115	Alliance of Genome Resources
DOID:14503	neuronal ceroid lipofuscinosis	Alliance of Genome Resources
DOID:1927	sphingolipidosis	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 72 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Cercocebus atys	105583651			CERAT17155
Propithecus coquereli	105817014			PROCO25797
Salmo salar	106602867			SALSA120695
Cyprinodon variegatus	107098736			CYPVA24340
Sinocyclocheilus grahami	107587355			SINGR09790
Sinocyclocheilus grahami	107597455			SINGR11798
Kryptolebias marmoratus	108233906			KRYMA08085
Ictalurus punctatus	108260118			ICTPU23091
Pygocentrus nattereri	108429747			PYGNA12204
Rhinopithecus bieti	108520724			RHIBE40339

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024