GlyCosmos Portal

Annotation

Keyword

Calcium
Endoplasmic reticulum
Hydrolase
Metal-binding
Reference proteome
Sphingolipid metabolism
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TDN7	Acylsphingosine deacylase 3 N-acylsphingosine amidohydrolase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
sebaceous gland development	IEA
cellular response to calcium ion	IDA	17713573
response to alkaline pH	IDA	17713573
sphingosine biosynthetic process	IBA IDA IMP	17713573 20207939 20628055
keratinocyte differentiation	IEP	16477081

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

sphingolipid catabolic process

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

sphingoid biosynthetic process [inference]

sphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

ceramide catabolic process

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

animal organ development [inference]

gland development [inference]

sebaceous gland development

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to alkaline pH

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	17713573
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acylsphingosine amidohydrolase activity	IDA TAS	17713573
ceramidase activity	IEA
dihydroceramidase activity	IBA IDA IMP	20207939 20628055
metal ion binding	IEA
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

dihydroceramidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

dihydroceramidase activity

ceramidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01441

Name

alkaline ceramidase [EC:3.5.1.23]

References

12783875

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:987	alopecia	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000475
Gene Name: alkaline ceramidase 1

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	189124	WB:WBGene00020947
Drosophila melanogaster	250736	FB:FBgn0045064
Callorhinchus milii	103183483		CALMI27637
Latimeria chalumnae	102358287		LATCH17742
Danio rerio	550266	ZFIN:ZDB-GENE-050417-70	DANRE43443
Ictalurus punctatus	108264991		ICTPU30349
Electrophorus electricus	113591857		ELEEL47517
Salmo salar	106613843		SALSA06603
Salmo trutta	115158328		SALTR109217
Oryzias latipes	101170916		ORYLA13211

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements