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cadherin, EGF LAG seven-pass G-type receptor 1

Summary

Gene Symbol

Celsr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12614

PubChem

12614

Alliance of Genome Resources

MGI:1100883

Annotation

Keyword

Calcium
Cell membrane
Developmental protein
Disulfide bond
EGF-like domain
G-protein coupled receptor
Glycoprotein
Hydroxylation
Laminin EGF-like domain
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O35161

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity	IMP	12842012
neural tube closure	IMP	12842012
neural tube closure	IGI	17229766
hair follicle development	IMP	18849982
homophilic cell adhesion via plasma membrane adhesion molecules	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

behavior [inference]

locomotory behavior

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

establishment of planar polarity of embryonic epithelium

establishment of body hair or bristle planar orientation [inference]

establishment of body hair planar orientation

embryonic morphogenesis [inference]

inner ear morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in lung branching [inference]

lateral sprouting from an epithelium [inference]

lateral sprouting involved in lung morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

hair follicle development

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity [inference]

regulation of establishment of planar polarity involved in neural tube closure [inference]

planar cell polarity pathway involved in neural tube closure

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway [inference]

Wnt signaling pathway, planar cell polarity pathway [inference]

planar cell polarity pathway involved in neural tube closure

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
plasma membrane	ISO
plasma membrane	IEA
membrane	IDA	20353824

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
calcium ion binding	TAS	12842012
protein binding	IPI	18849982 23292348

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 6** entries
InterPro
Cadherin conserved site
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	1951	FB:FBgn0024836
Drosophila melanogaster	1952	FB:FBgn0024836
Homo sapiens	9620	Xenbase:XB-GENE-853455	HUMAN61100
Xenopus tropicalis	12614	Xenbase:XB-GENE-853455
Xenopus tropicalis	36125	Xenbase:XB-GENE-853455
Drosophila melanogaster	53883	FB:FBgn0024836
Drosophila melanogaster	83466	FB:FBgn0024836
Drosophila melanogaster	107934	FB:FBgn0024836
Xenopus tropicalis	179788	Xenbase:XB-GENE-853455
Rattus norvegicus	300128		RATNO37411

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Acknowledgements