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cyclic nucleotide gated channel subunit alpha 3

Summary

Gene Symbol

CNGA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1261

PubChem

1261

Alliance of Genome Resources

HGNC:2150

Annotation

Keyword

3D-structure
Alternative splicing
Calcium channel
Cell membrane
Coiled coil
Disease variant
Glycoprotein
Leber congenital amaurosis
Ligand-gated ion channel
Reference proteome
Sodium channel
Transmembrane helix
Vision
cGMP-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16281	Cone photoreceptor cGMP-gated channel subunit alpha-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
monoatomic cation transport	IMP	24164424
signal transduction	TAS	9517456
visual perception	IEA
response to magnesium ion	IEA
sodium ion transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to inorganic substance [inference]

response to metal ion [inference]

response to magnesium ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	12815043
plasma membrane	IBA
intracellular cyclic nucleotide activated cation channel complex	IBA
dendrite	IEA
axon initial segment	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

intracellular cyclic nucleotide activated cation channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

intracellular cyclic nucleotide activated cation channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

glial cell projection

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
intracellular cAMP-activated cation channel activity	IDA	12815043
intracellular cAMP-activated cation channel activity	IBA
intracellular cGMP-activated cation channel activity	IDA	12815043
intracellular cGMP-activated cation channel activity	IMP	24164424
intracellular cGMP-activated cation channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

myosin binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

cGMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

ion binding [inference]

anion binding [inference]

cGMP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

cGMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cyclic nucleotide-gated cation channel

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cGMP binding
intracellular cAMP-activated cation channel activity
intracellular cGMP-activated cation channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 5** entries
InterPro
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
Cyclic nucleotide-binding, conserved site
Ion transport domain
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110007	achromatopsia 2	Alliance of Genome Resources
DOID:13399	color blindness	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 89 in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	707872	MACMU08361
Monodelphis domestica	100013116	MONDO32495
Equus caballus	100061333	HORSE10553
Taeniopygia guttata	100222773	TAEGU11433
Ovis aries	100233164	SHEEP14072
Callithrix jacchus	100394541	CALJA10603
Pongo abelii	100454008	PONAB22784
Ailuropoda melanoleuca	100482929	AILME12051
Meleagris gallopavo	100551039	MELGA01502
Nomascus leucogenys	100591608	NOMLE08060