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cryptic, EGF-CFC family member 1

Summary

Gene Symbol

Cfc1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12627

PubChem

12627

Alliance of Genome Resources

MGI:109448

Annotation

Keyword

Cell membrane
Disulfide bond
EGF-like domain
GPI-anchor
Gastrulation
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P97766

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
anterior/posterior pattern specification	IBA IGI	11412024
atrial septum morphogenesis	IMP	10521397
digestive tract morphogenesis	IMP	10521397
heart looping	IMP	10521397
heart development	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway [inference]

nodal signaling pathway

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

post-embryonic development

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

lung morphogenesis [inference]

left lung morphogenesis

tube morphogenesis [inference]

digestive tract morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

gastrulation

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

cardiac septum morphogenesis [inference]

atrial septum morphogenesis

anatomical structure development

blood vessel development

coronary vasculature development

tissue development [inference]

endoderm development

animal organ development [inference]

heart development

hematopoietic or lymphoid organ development [inference]

spleen development

gland development [inference]

liver development

system development [inference]

respiratory system development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway [inference]

nodal signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
side of membrane	IEA
extracellular region	IBA IEA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
activin receptor binding	IBA IPI	12052855
nodal binding	IBA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor serine/threonine kinase binding [inference]

transmembrane receptor protein serine/threonine kinase binding [inference]

activin receptor binding

nodal binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Teratocarcinoma-derived growth factor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
activin receptor binding
anterior/posterior pattern specification
blood vessel development
determination of left/right symmetry
nodal binding
nodal signaling pathway

Displaying **all 2** entries
InterPro
Cryptic/Cripto, CFC domain
EGF-like domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0060770	dextro-looped transposition of the great arteries	Alliance of Genome Resources
DOID:0060856	right atrial isomerism	Alliance of Genome Resources
DOID:6406	double outlet right ventricle	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	55997		HGNC:18292	HUMAN64737
Pan troglodytes	459608			PANTR28657
Rattus norvegicus	501121	10116_1:003333	RGD:1562188	RATNO43765
Homo sapiens	653275		HGNC:33983	HUMAN64736
Pongo abelii	100436096			PONAB24224
Nomascus leucogenys	100600217			NOMLE19156
Cricetulus griseus	100756508	10029_0:000a04		CRIGR26369
Heterocephalus glaber	101709058	10181_0:000388
Cavia porcellus	101787576	10141_0:00474e
Mesocricetus auratus	101827682	10036_0:0035b7

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements