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cannabinoid receptor 2

Summary

Gene Symbol

CNR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1269

PubChem

1269

Alliance of Genome Resources

HGNC:2160

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
G-protein coupled receptor
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P34972	CX5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cannabinoid signaling pathway	IEA
negative regulation of mast cell activation	IEA
negative regulation of action potential	IEA
regulation of metabolic process	IBA
leukocyte chemotaxis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cannabinoid signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to lipid [inference]

response to lipopolysaccharide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

regulation of metabolic process

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

trans-synaptic signaling by lipid [inference]

trans-synaptic signaling by endocannabinoid [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of action potential

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cannabinoid signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

trans-synaptic signaling, modulating synaptic transmission [inference]

trans-synaptic signaling by lipid, modulating synaptic transmission [inference]

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of mast cell activation [inference]

negative regulation of mast cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of mast cell activation

regulation of action potential [inference]

negative regulation of action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

negative regulation of action potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IEA
perikaryon	IEA
plasma membrane	IBA TAS
dendrite	IEA
endoplasmic reticulum	IDA	28364261

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31616248 32296183
cannabinoid receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

cannabinoid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cannabinoid receptor 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cannabinoid receptor activity
cannabinoid signaling pathway

Displaying **all 4** entries
InterPro
Cannabinoid receptor family
Cannabinoid receptor type 1
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources
DOID:848	arthritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12802		MGI:104650	MOUSE40979
Rattus norvegicus	57302		RGD:619713	RATNO32800
Pan troglodytes	456625	9598_0:000325		PANTR20244
Bos taurus	539769			BOVIN25195
Canis lupus familiaris	612289			CANLF07027
Macaca mulatta	711155			MACMU22214
Danio rerio	795246		ZFIN:ZDB-GENE-040702-7
Monodelphis domestica	100010312			MONDO25024
Equus caballus	100071536			HORSE27465
Ornithorhynchus anatinus	100091779			ORNAN08414