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Guidelines

MIRAGE

tripeptidyl peptidase I

Summary

Gene Symbol

Tpp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12751

PubChem

12751

Alliance of Genome Resources

MGI:1336194

Annotation

Keyword

Autocatalytic cleavage
Calcium
Disulfide bond
Glycoprotein
Lysosome
Metal-binding
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O89023	Lysosomal pepstatin-insensitive protease Tripeptidyl aminopeptidase Tripeptidyl-peptidase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
proteolysis	ISS	14609438
proteolysis	ISO
proteolysis	IBA
lysosome organization	IMP	15483130
nervous system development	ISS	14609438

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

developmental process [inference]

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA	14651853
lysosome	ISS	14609438
lysosome	ISO
lysosome	IDA	19941651
Golgi apparatus	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISS	14609438
endopeptidase activity	ISO
endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
protein binding	IPI	17053789 19941651

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

amide binding [inference]

peptide binding

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

deacetylase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
NAD+ binding
metal ion binding
transferase activity

Displaying **all 3** entries
InterPro
DHS-like NAD/FAD-binding domain superfamily
Sirtuin family, catalytic core domain
Sirtuin family

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110726	neuronal ceroid lipofuscinosis 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1200	Xenbase:XB-GENE-997325	HUMAN04344
Xenopus tropicalis	12751	Xenbase:XB-GENE-997325
Rattus norvegicus	83534	Xenbase:XB-GENE-997325	RATNO18209
Pan troglodytes	450999		PANTR02210
Canis lupus familiaris	485337		CANLF08472
Bos taurus	515575		BOVIN06903
Macaca mulatta	709838		MACMU10383
Danio rerio	798347	Xenbase:XB-GENE-997325	DANRE12913
Monodelphis domestica	100030970		MONDO23702
Equus caballus	100070095		HORSE38706

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025