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ATP-binding cassette, sub-family member 2

Summary

Gene Symbol

Abcc2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12780

PubChem

12780

Alliance of Genome Resources

MGI:1352447

Annotation

Keyword

ATP-binding
Cell membrane
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VI47	Canalicular multispecific organic anion transporter 1 Multidrug resistance-associated protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	ISO
xenobiotic transmembrane transport	IEA
response to xenobiotic stimulus	ISO
negative regulation of gene expression	ISO
mercury ion transport	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

antibiotic metabolic process

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

secondary metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

sulfur compound metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

organic cyclic compound metabolic process [inference]

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

sulfur compound metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

xenobiotic metabolic process [inference]

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

heterocycle metabolic process [inference]

lactam metabolic process [inference]

beta-lactam antibiotic metabolic process [inference]

penicillin metabolic process [inference]

benzylpenicillin metabolic process

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

mercury ion transport

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export from cell [inference]

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

inorganic ion homeostasis [inference]

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to estrogen

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

mercury ion transport

monoatomic cation transmembrane transport [inference]

mercury ion transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

hormone transport [inference]

thyroid hormone transport

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic transmembrane transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

secretion [inference]

canalicular bile acid transport

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

mercury ion transport

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

mercury ion transport

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

transepithelial transport

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

organic anion transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

bilirubin transport

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

bilirubin transport

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

organic hydroxy compound transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

nitrogen compound transport [inference]

bilirubin transport

export from cell [inference]

xenobiotic export from cell

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

thyroid hormone transport

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of mercury ion

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GO Term	Evidence Code	PMID
plasma membrane	IDA	12951053
cell surface	ISO
cell surface	IEA
membrane	IDA	11279518
apical plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

intracellular canaliculus

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12068294
ATP binding	IEA
ABC-type xenobiotic transporter activity	ISO
ABC-type xenobiotic transporter activity	IEA
bilirubin transmembrane transporter activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

bilirubin transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

bilirubin transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

protein binding

protein domain specific binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **31 - 40** of 90 in total

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Species	Gene ID	Orthologous MAtrix
Loxodonta africana	100666918	LOXAF15528
Cricetulus griseus	100689220	CRIGR23027
Oreochromis niloticus	100703684	ORENI12642
Oreochromis niloticus	100707969	ORENI12642
Oreochromis niloticus	100708240	ORENI12642
Oreochromis niloticus	100708777	ORENI12642
Cavia porcellus	100718828	CAVPO00655
Sarcophilus harrisii	100925041	SARHA02224
Otolemur garnettii	100951440	OTOGA14259
Pan paniscus	100993869	PANPA05318

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Acknowledgements