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ciliary neurotrophic factor receptor

Summary

Gene Symbol

Cntfr

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12804

PubChem

12804

Alliance of Genome Resources

MGI:99605

Annotation

Keyword

Cell membrane
Disulfide bond
GPI-anchor
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O88507

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
suckling behavior	IMP	7585948
brainstem development	IMP	7585948
sex differentiation	IMP	10526311
positive regulation of cell population proliferation	IGI	15051883
positive regulation of cell population proliferation	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

ciliary neurotrophic factor-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

reproductive process [inference]

developmental process involved in reproduction [inference]

sex differentiation

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

suckling behavior

developmental process [inference]

developmental process involved in reproduction [inference]

sex differentiation

anatomical structure development [inference]

brainstem development

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

ciliary neurotrophic factor-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
apical plasma membrane	ISO
apical plasma membrane	IEA
ciliary neurotrophic factor receptor complex	ISO
ciliary neurotrophic factor receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

CNTFR-CLCF1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

ciliary neurotrophic factor receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

side of membrane

external side of plasma membrane

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GO Term	Evidence Code	PMID
ciliary neurotrophic factor receptor activity	ISO
ciliary neurotrophic factor receptor activity	IGI	7585948
interleukin-11 receptor activity	IBA
signaling receptor binding	ISO
signaling receptor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

growth factor binding [inference]

interleukin-11 binding

cytokine binding

interleukin-11 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

immune receptor activity [inference]

cytokine receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ciliary neurotrophic factor receptor

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ciliary neurotrophic factor receptor activity
cytokine-mediated signaling pathway

Displaying **all 7** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin subtype 2
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Long hematopoietin receptor, soluble alpha chain, conserved site

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1271	Xenbase:XB-GENE-923386	HUMAN96810
Xenopus tropicalis	12804	Xenbase:XB-GENE-923386
Rattus norvegicus	313173	Xenbase:XB-GENE-923386	RATNO32928
Danio rerio	368438		DANRE01286
Canis lupus familiaris	442941		CANLF02259
Pan troglodytes	473218		PANTR43855
Macaca mulatta	700959		MACMU12506
Monodelphis domestica	100028872		MONDO28260
Ornithorhynchus anatinus	100088663		ORNAN18484
Equus caballus	100146590		HORSE22254

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements