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MIRAGE

collagen, type V, alpha 1

Summary

Gene Symbol

Col5a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12831

PubChem

12831

Alliance of Genome Resources

MGI:88457

Annotation

Keyword

Alternative splicing
Collagen
Extracellular matrix
Heparin-binding
Hydroxylation
Reference proteome
Repeat
Signal
Sulfation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O88207
B1AWB9

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
blood vessel development	IMP	16492673
heart morphogenesis	IGI	17029294
cell adhesion	ISO
cell adhesion	IBA
cell adhesion	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

collagen biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

cellular process [inference]

cell adhesion

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

cell motility [inference]

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization

collagen fibril organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis

anatomical structure development [inference]

blood vessel development

tissue development [inference]

connective tissue development [inference]

tendon development

animal organ development [inference]

skin development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of cellular component organization

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
collagen trimer	IDA	15383546 17683922
collagen trimer	IMP	16492673
collagen type V trimer	ISO
collagen type V trimer	IBA
collagen type V trimer	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

fibrillar collagen trimer [inference]

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	IDA	15383546
protein binding	IPI	14676276
heparin binding	ISO
heparin binding	IBA
heparin binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding

growth factor binding [inference]

platelet-derived growth factor binding

proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen alpha

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
extracellular matrix structural constituent conferring tensile strength
extracellular matrix structural constituent

Displaying **all 2** entries
InterPro
Collagen triple helix repeat
Fibrillar collagen, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14720	Ehlers-Danlos syndrome classic type 1	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1289	Xenbase:XB-GENE-5954567	HUMAN99186
Xenopus tropicalis	12831	Xenbase:XB-GENE-5954567
Rattus norvegicus	85490		RATNO27593
Sus scrofa	397533		PIGXX16446
Macaca mulatta	722014		MACMU13371
Ornithorhynchus anatinus	100074710		ORNAN21008
Taeniopygia guttata	100228206		TAEGU06766
Danio rerio	100334431		DANRE20596
Pongo abelii	100434171		PONAB35649
Cavia porcellus	100724382		CAVPO12503

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025