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Guidelines

MIRAGE

collagen, type VII, alpha 1

Summary

Gene Symbol

Col7a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12836

PubChem

12836

Alliance of Genome Resources

MGI:88462

Annotation

Keyword

3D-structure
Basement membrane
Cell adhesion
Collagen
Disulfide bond
Glycoprotein
Hydroxylation
Reference proteome
Repeat
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63870	Long-chain collagen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cell adhesion	IEA
negative regulation of peptidase activity
extracellular matrix organization	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
extracellular region	TAS
collagen trimer	IEA
basement membrane	IDA	18757743 19651211
basement membrane	IBA
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IEA
extracellular matrix structural constituent conferring tensile strength	RCA	22159717 28071719
extracellular matrix structural constituent conferring tensile strength	IBA
identical protein binding	IPI	21570975

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding [inference]

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen alpha-1(VII) chain

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
extracellular matrix structural constituent conferring tensile strength
serine-type endopeptidase inhibitor activity

Displaying **all 9** entries
InterPro
Collagen triple helix repeat
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Pancreatic trypsin inhibitor Kunitz domain superfamily
Pancreatic trypsin inhibitor Kunitz domain
Proteinase inhibitor I2, Kunitz, conserved site
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060642	recessive dystrophic epidermolysis bullosa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 23 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1294	ZFIN:ZDB-GENE-030131-2427	HUMAN69852
Danio rerio	12836	ZFIN:ZDB-GENE-030131-2427
Rattus norvegicus	301012		RATNO41433
Danio rerio	100332562		DANRE38678
Callithrix jacchus	100385760		CALJA12506
Sus scrofa	100523209		PIGXX04023
Nomascus leucogenys	100592937		NOMLE28614
Loxodonta africana	100675093		LOXAF14780
Cricetulus griseus	100689027		CRIGR12479
Sarcophilus harrisii	100928875		SARHA14891

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Last updated: December 8, 2025