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cytochrome c oxidase subunit 5A

Summary

Gene Symbol

Cox5a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12858

PubChem

12858

Alliance of Genome Resources

MGI:88474

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Heme
Mitochondrion inner membrane
Phosphoprotein
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P12787	Cytochrome c oxidase polypeptide Va

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrial electron transport, cytochrome c to oxygen	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

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GO Term	Evidence Code	PMID
myelin sheath	HDA	17634366

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

respiratory chain complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	31536960
metal ion binding	IEA
cytochrome-c oxidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

cytochrome c oxidase subunit 5A, mitochondrial

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
mitochondrial electron transport, cytochrome c to oxygen
oxidative phosphorylation

Displaying **all 2** entries
InterPro
Cytochrome c oxidase, subunit Va/VI superfamily
Cytochrome c oxidase, subunit Va/VI

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0060340	ciliopathy	Alliance of Genome Resources
DOID:0070505	mitochondrial complex IV deficiency nuclear type 20	Alliance of Genome Resources
DOID:3762	cytochrome-c oxidase deficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Marmota flaviventris	114082634	93162_0:00061f
Grammomys surdaster	114626879	491861_0:001f1e
Peromyscus leucopus	114690344	10041_0:002615
Strigops habroptila	115613231			STRHB23438
Mastomys coucha	116071976	35658_0:003968
Rattus rattus	116908089	10117_0:0030db
Arvicanthis niloticus	117698983	61156_0:005095
Onychomys torridus	118587956	38674_0:002302
Arvicola amphibius	119808969	1047088_0:000f9e
Microtus oregoni	121443068	111838_0:005c5f

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024