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Guidelines

MIRAGE

collagen type V alpha 1 chain

Summary

Gene Symbol

COL5A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1289

PubChem

1289

Alliance of Genome Resources

HGNC:2209

JoGo

COL5A1

TogoVar

COL5A1

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Collagen
Direct protein sequencing
Disease variant
Disulfide bond
Ehlers-Danlos syndrome
Extracellular matrix
Heparin-binding
Hydroxylation
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal
Sulfation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q59EE7
B2ZZ86
P20908

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
blood vessel development	IEA
heart morphogenesis	IEA
cell adhesion	IMP	18305566
cell adhesion	IBA
cell migration	IMP	18305566

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

collagen biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

cellular process [inference]

cell adhesion

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

integrin biosynthetic process

cell motility [inference]

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization

collagen fibril organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis

anatomical structure development [inference]

blood vessel development

tissue development [inference]

connective tissue development [inference]

tendon development

animal organ development [inference]

skin development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of endodermal cell differentiation [inference]

negative regulation of endodermal cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of endodermal cell differentiation

regulation of cellular component organization

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	HDA	27068509
collagen type V trimer	NAS	37158802
collagen type V trimer	IMP	9683580
collagen type V trimer	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer [inference]

fibrillar collagen trimer [inference]

collagen type V trimer

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
integrin binding	NAS	14970208
protein binding	IPI	20979576 28514442 33961781
heparin binding	IDA	2203476
heparin binding	IBA
extracellular matrix structural constituent conferring tensile strength	RCA	20551380 25037231 27559042 28327460 28675934

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

growth factor binding [inference]

platelet-derived growth factor binding

proteoglycan binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen alpha

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
extracellular matrix structural constituent conferring tensile strength
extracellular matrix structural constituent

Displaying **all 2** entries
InterPro
Collagen triple helix repeat
Fibrillar collagen, C-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:14720	Ehlers-Danlos syndrome classic type 1	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025