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Standards Ontologies Notations
alcohol dehydrogenase 5 (class III), chi polypeptide

Summary
Gene Symbol
  • ADH5
Aliases
  • ADH-3
  • ADHX
  • GSNOR
  • S-nitrosoglutathione reductase
Organism
Homo sapiens (human)
External Links
NCBI Gene
128
HGNC
253
KEGG Gene ID
hsa:128
PubChem
128
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Dwarfism
  • Intellectual disability
  • Lipid metabolism
  • Metal-binding
  • NAD
  • Oxidoreductase
  • Phosphoprotein
  • Reference proteome
  • Zinc
Proteins
Displaying all 2 entries
UniProt Protein Name
P11766
  • Alcohol dehydrogenase 5
  • Alcohol dehydrogenase class chi chain
  • Alcohol dehydrogenase class-III
  • Glutathione-dependent formaldehyde dehydrogenase
  • S-(hydroxymethyl)glutathione dehydrogenase
Q6IRT1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
response to lipopolysaccharide
response to redox state
fatty acid omega-oxidation
retinoid metabolic process
formaldehyde catabolic process
GO Hierarchy
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
electron transfer activity
S-(hydroxymethyl)glutathione dehydrogenase NADP activity
zinc ion binding
S-(hydroxymethyl)glutathione dehydrogenase NAD activity
alcohol dehydrogenase activity, zinc-dependent
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000197894

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
KEGG BRITE Database
Orthology
K00121
Name
S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
References
Rhea

RHEA:19981

NADP+ + S-(hydroxymethyl)glutathione
H+ + S-formylglutathione + NADPH
Enzyme
PMID

RHEA:19985

NAD+ + S-(hydroxymethyl)glutathione
H+ + S-formylglutathione + NADH
Enzyme
PMID

RHEA:10736

a primary alcohol + NAD+
H+ + an aldehyde + NADH
Enzyme
PMID

RHEA:10740

a secondary alcohol + NAD+
H+ + a ketone + NADH
Enzyme
PMID

RHEA:25290

ethanol + NAD+
acetaldehyde + H+ + NADH
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 31 - 40 of 118 in total
DO ID Disease Name Source
DOID:0090093 hypogonadotropic hypogonadism 21 with or without anosmia
DOID:0090094 hypogonadotropic hypogonadism 1 with or without anosmia
DOID:0110741 type 1 diabetes mellitus 2
DOID:0110742 type 1 diabetes mellitus 3
DOID:0110743 type 1 diabetes mellitus 4
DOID:0110744 type 1 diabetes mellitus 5
DOID:0110745 type 1 diabetes mellitus 6
DOID:0110746 type 1 diabetes mellitus 7
DOID:0110747 type 1 diabetes mellitus 8
DOID:0110748 obsolete type 1 diabetes mellitus 9
The Human Phenotype Ontology
Displaying entries 11 - 19 of 19 in total
HPO ID HPO Term
HP:0001882 Leukopenia
HP:0001903 Anemia
HP:0002863 Myelodysplasia
HP:0004322 Short stature
HP:0004808 Acute myeloid leukemia
HP:0005301 Persistent left superior vena cava
HP:0005528 Bone marrow hypocellularity
HP:0007018 Attention deficit hyperactivity disorder
HP:0010984 Digenic inheritance
Displaying 1 entry
Disease ID Disease Name
OMIM:619151
  • AMED syndrome, digenic
PubChem Disease
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000519
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Ortholog
Displaying entries 71 - 80 of 87 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
119620184 CHLSB16548
108531854 RHIBE03484
104664094 RHIRO40387
100592499 NOMLE37755
114603909 PODMU29592
107586060 SINGR28009
106846359 EQUAS07062
116815019 CHEAB13867
105289535 PTEVA06457
115049581 ECHNA29445
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Last updated: August 19, 2024