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phosphatase and tensin homolog

Summary

Gene Symbol

PTEN

Organism

Nyctereutes procyonoides (raccoon dog)

External Links

NCBI Gene: 129507556
KEGG Gene ID: npo:129507556
PubChem: 129507556

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA	30032202
phosphatidylinositol dephosphorylation	IEA	22301074 30032202
negative regulation of cell population proliferation	IEA	22301074 30032202
protein dephosphorylation	IEA	22301074 30032202
cell motility	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cell motility

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
cell projection	IEA	30032202
nucleus	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IEA	22301074 30032202
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA	22301074
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA	22301074 30032202
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

inositol phosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Carnivora

Group Name

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying entries **11 - 13** of 13 in total

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Gene Ontology
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 9** entries
InterPro
Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
C2 domain superfamily
PTEN, phosphatase domain
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tensin phosphatase, C2 domain
Tensin-type phosphatase domain
Tyrosine-specific protein phosphatases domain

KEGG BRITE Database

Orthology

K01110

Name

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]

References

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	OrthoDB
Canis lupus familiaris	403832	9615_1:004101
Ailuropoda melanoleuca	100469483	9646_0:001a3a
Felis catus	101091813	9685_0:00362d
Odobenus rosmarus divergens	101367385	9708_0:003318
Leptonychotes weddellii	102744825	9713_0:0011d9
Panthera tigris	102972446	9694_0:0035ee
Ursus maritimus	103661921	29073_0:004bae
Acinonyx jubatus	106980972	32536_0:002a85
Panthera pardus	109255395	9691_0:002d6e
Neomonachus schauinslandi	110586061	29088_0:001d09