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cathepsin L

Summary

Gene Symbol

Ctsl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13039

PubChem

13039

Alliance of Genome Resources

MGI:88564

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Metal-binding
Reference proteome
Secreted
Signal
Thiol protease
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q543M3
P06797	Cathepsin L1 Major excreted protein p39 cysteine proteinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 31 in total

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GO Term	Evidence Code	PMID
male gonad development	ISS
cellular response to starvation	ISS
response to glucose	ISS
negative regulation of keratinocyte proliferation	IMP	11023992
response to organic cyclic compound

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide antigen

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

enkephalin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

enkephalin processing

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

elastin metabolic process [inference]

elastin catabolic process

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

organonitrogen compound catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

catabolic process [inference]

collagen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

collagen metabolic process [inference]

collagen catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

enkephalin processing

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

elastin metabolic process [inference]

elastin catabolic process

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

elastin metabolic process [inference]

elastin catabolic process

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

elastin metabolic process [inference]

elastin catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

enkephalin processing

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

elastin metabolic process [inference]

elastin catabolic process

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

enkephalin processing

organonitrogen compound catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

elastin catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

glycoprotein catabolic process [inference]

elastin catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cell death [inference]

programmed cell death [inference]

autophagic cell death

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

Sertoli cell differentiation

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell differentiation

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

molting cycle process [inference]

hair cycle process [inference]

hair follicle morphogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

Sertoli cell differentiation

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

hair follicle morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

anatomical structure development [inference]

tissue development [inference]

decidualization

nerve development

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

Sertoli cell differentiation

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment

biological phase [inference]

hair cycle phase [inference]

catagen

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organic cyclic compound

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of epithelial cell proliferation [inference]

regulation of keratinocyte proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of keratinocyte proliferation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

enkephalin processing

thyroid hormone metabolic process [inference]

thyroid hormone generation

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	10716919 12417635 12782676 9310336
extracellular space	IBA
nucleus	IDA	18957203
nucleolus	IDA	20338168

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome [inference]

multivesicular body

secretory vesicle [inference]

secretory granule

chromaffin granule

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome [inference]

multivesicular body

secretory vesicle [inference]

secretory granule

chromaffin granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

late endosome [inference]

multivesicular body

secretory vesicle [inference]

secretory granule

chromaffin granule

intracellular non-membrane-bounded organelle [inference]

nucleolus

apical part of cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
fibronectin binding	ISO
endopeptidase activity	IMP	18450756 28835281
aminopeptidase activity	ISS
aminopeptidase activity	ISO
cysteine-type endopeptidase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

carboxypeptidase activity [inference]

cysteine-type carboxypeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

carboxypeptidase activity [inference]

cysteine-type carboxypeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

collagen binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 7** entries
Gene Ontology
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
hydrolase activity
immune response
positive regulation of apoptotic signaling pathway
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements