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cytochrome P450, family 1, subfamily a, polypeptide 2

Summary

Gene Symbol

Cyp1a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13077

PubChem

13077

Alliance of Genome Resources

MGI:88589

Annotation

Keyword

Direct protein sequencing
Fatty acid metabolism
Glycoprotein
Heme
Lipid metabolism
Lyase
Membrane
Microsome
Monooxygenase
Reference proteome
Sterol metabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B6VGH4
P00186	CYPIA2 Cholesterol 25-hydroxylase Cytochrome P450-P2 Cytochrome P450-P3 Hydroperoxy icosatetraenoate dehydratase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
steroid catabolic process	ISO
steroid catabolic process	IEA
porphyrin-containing compound metabolic process	IMP	11274970 9461503
xenobiotic metabolic process	ISO
xenobiotic metabolic process	IMP	8643688

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

alkaloid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

secondary metabolic process [inference]

toxin metabolic process

toxin biosynthetic process

secondary metabolite biosynthetic process [inference]

toxin biosynthetic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process

toxin biosynthetic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

steroid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

dibenzo-p-dioxin metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

steroid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

olefinic compound metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

cellular aromatic compound metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process

toxin biosynthetic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

heterocycle metabolic process [inference]

dibenzo-p-dioxin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to cadmium ion [inference]

cellular response to cadmium ion

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to cadmium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA
intracellular membrane-bounded organelle	ISO
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISO
monooxygenase activity	IBA
iron ion binding	IEA
oxidoreductase activity	ISO
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [inference]

nitrite reductase (NO-forming) activity

nitrite reductase activity [inference]

nitrite reductase (NO-forming) activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [inference]

caffeine oxidase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

hydroperoxy icosatetraenoate dehydratase activity

demethylase activity

binding [inference]

protein binding [inference]

enzyme binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements