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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
catechol-O-methyltransferase
Summary
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21964 |
|
| A0A140VJG8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to oxidative stress | ||
| cellular response to phosphate starvation | ||
| methylation | ||
| visual learning | ||
| response to wounding |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| L-dopa O-methyltransferase activity |
|
|
| orcinol O-methyltransferase activity |
|
|
| protein binding | ||
| catechol O-methyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10825 | essential hypertension | |
| DOID:1089 | tethered spinal cord syndrome | |
| DOID:10892 | hypospadias | |
| DOID:10907 | microcephaly | |
| DOID:10908 | hydrocephalus | |
| DOID:10914 | amnestic disorder | |
| DOID:10915 | Wernicke-Korsakoff syndrome | |
| DOID:10923 | sickle cell anemia | |
| DOID:10930 | borderline personality disorder | |
| DOID:10932 | obsessive-compulsive personality disorder |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0005562 | Multiple renal cysts |
| HP:0006510 | Chronic pulmonary obstruction |
| HP:0007018 | Attention deficit hyperactivity disorder |
| HP:0007086 | Social and occupational deterioration |
| HP:0007302 | Bipolar affective disorder |
| HP:0008872 | Feeding difficulties in infancy |
| HP:0011324 | Multiple suture craniosynostosis |
| HP:0011496 | Corneal neovascularization |
| HP:0011662 | Tricuspid atresia |
| HP:0012303 | Abnormal aortic arch morphology |
| Disease ID | Disease Name |
|---|---|
| OMIM:181500 |
|
| ORPHA:567 |
|
| OMIM:167870 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 104681986 | RHIRO39893 | ||
| 114586245 | PODMU27645 | ||
| 107553993 | SINGR08682 | ||
| 107584930 | SINGR34375 | ||
| 107601759 | SINGR65043 | ||
| 116819462 | CHEAB13616 | ||
| 115043895 | ECHNA05008 | ||
| 115388414 | SALFA35247 | ||
| 113485994 | ATHCN16216 | ||
| 109098298 | CYPCA119631 |
