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COPI coat complex subunit alpha

Summary

Gene Symbol

COPA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1314

PubChem

1314

Alliance of Genome Resources

HGNC:2230

JoGo

COPA

TogoVar

COPA

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disease variant
ER-Golgi transport
Golgi apparatus
Hormone
Membrane
Methylation
Phosphoprotein
Protein transport
Proteomics identification
RNA editing
Reference proteome
Repeat
Secreted
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P53621	Alpha-coat protein HEP-COP

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IBA
endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
intra-Golgi vesicle-mediated transport	IBA
signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

intracellular transport [inference]

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
extracellular space	IDA	1429581
cytoplasm	IDA	9115636
endoplasmic reticulum membrane	TAS
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

vesicle coat [inference]

COPI vesicle coat

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

site of polarized growth [inference]

growth cone

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hormone activity	IEA
structural molecule activity	IEA
protein binding	IPI	16169070 25051373 30352685 33961781 35271311

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

coatomer, alpha subunit

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intra-Golgi vesicle-mediated transport
structural molecule activity

Displaying **all 9** entries
InterPro
Coatomer subunit alpha, WD Associated Region
Coatomer subunit alpha
Coatomer, WD associated region
Coatomer, alpha subunit, C-terminal
G-protein beta WD-40 repeat
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily