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dynactin 1

Summary

Gene Symbol

Dctn1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13191

PubChem

13191

Alliance of Genome Resources

MGI:107745

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoskeleton
Dynein
Microtubule
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transport
Ubl conjugation

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q6NZM3
E9Q586
E9Q3M3
O08788	150 kDa dynein-associated polypeptide DAP-150 p150-glued
Q3TRF1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 38 in total

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GO Term	Evidence Code	PMID
positive regulation of microtubule polymerization	ISS
positive regulation of microtubule polymerization	ISO
cytoplasmic microtubule organization	ISS
melanosome transport	IMP	22275436
microtubule anchoring at centrosome	ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cell cycle process [inference]

centriole-centriole cohesion

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell division

cellular localization [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cellular component disassembly [inference]

membrane disassembly [inference]

nuclear membrane disassembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

neuron projection organization [inference]

neuron projection maintenance

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

membrane organization [inference]

membrane disassembly [inference]

nuclear membrane disassembly

nuclear membrane organization [inference]

nuclear membrane disassembly

supramolecular fiber organization [inference]

cytoplasmic microtubule organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process

behavior [inference]

motor behavior

developmental process [inference]

anatomical structure development [inference]

ventral spinal cord development

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

pigment granule transport [inference]

melanosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

organelle localization [inference]

nucleus localization [inference]

nuclear migration

vesicle localization [inference]

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

pigment granule localization [inference]

melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

nuclear migration

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of vesicle localization [inference]

establishment of pigment granule localization [inference]

establishment of melanosome localization [inference]

melanosome transport

pigment granule transport [inference]

melanosome transport

cellular localization [inference]

intracellular transport [inference]

nuclear migration

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of synapse organization [inference]

regulation of neuromuscular junction development [inference]

positive regulation of neuromuscular junction development

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of neuromuscular junction development

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

positive regulation of microtubule nucleation

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of microtubule nucleation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport

Displaying entries **26 - 30** of 43 in total

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GO Term	Evidence Code	PMID
retromer complex	ISO
retromer complex	IEA
cell leading edge	IDA	18331715
protein-containing complex	IDA	23523350
microtubule plus-end	ISO

GO Hierarchy

cellular component

protein-containing complex

microtubule associated complex

dynein complex

cytoplasmic dynein complex

membrane protein complex [inference]

retromer complex

intracellular protein-containing complex [inference]

centriolar subdistal appendage

catalytic complex [inference]

dynein complex

cytoplasmic dynein complex

cellular anatomical entity [inference]

spindle pole

cytoplasm

cell cortex

cell cortex region

cytoplasmic region [inference]

cell cortex region

microtubule organizing center [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

cell body [inference]

neuronal cell body

intercellular bridge

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	14581450 15242649 16632484 18331715 18615096 22073305 22956769 23386061 25189619 30787442 37871017
microtubule binding	ISO
microtubule binding	IDA	16954346
tubulin binding	ISO
protein kinase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding

microtubule binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cap-gly domain-containing linker protein

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytoplasmic microtubule organization
microtubule plus-end binding

Displaying **all 2** entries
InterPro
CAP Gly-rich domain superfamily
CAP Gly-rich domain

Ortholog

Displaying entries **11 - 20** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100174308	PONAB23439
Taeniopygia guttata	100230170	TAEGU23692
Oryctolagus cuniculus	100346609	RABIT08513
Callithrix jacchus	100401682	CALJA10966
Ailuropoda melanoleuca	100475411	AILME10492
Sus scrofa	100519249	PIGXX21774
Anolis carolinensis	100558573	ANOCA12524
Nomascus leucogenys	100585622	NOMLE08371
Loxodonta africana	100656316	LOXAF10990
Cavia porcellus	100714202	CAVPO15004

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements