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delta like non-canonical Notch ligand 1

Summary

Gene Symbol

Dlk1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13386

PubChem

13386

Alliance of Genome Resources

MGI:94900

Annotation

Keyword

Alternative splicing
Cytoplasm
Disulfide bond
EGF-like domain
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
G3UWU8
B4YB46
B4YB48
Q09163	Adipocyte differentiation inhibitor protein Preadipocyte factor 1
Q9DAU5
Q925U3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
ossification	IMP	21308776
osteoblast differentiation	IMP	21308776
positive regulation of cytokine production	IDA	21308776
embryo development	IDA	19247431
post-embryonic development	IDA	19247431

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

multicellular organismal process [inference]

ossification

multicellular organism development [inference]

embryo development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

growth [inference]

developmental growth [inference]

multicellular organism growth

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of vascular endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of osteoblast differentiation [inference]

negative regulation of osteoblast differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell differentiation [inference]

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

regulation of ossification [inference]

negative regulation of ossification

regulation of tissue remodeling [inference]

regulation of bone remodeling

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of myeloid cell differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

positive regulation of hemopoiesis [inference]

positive regulation of leukocyte differentiation [inference]

positive regulation of myeloid leukocyte differentiation [inference]

positive regulation of osteoclast differentiation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
cytoplasm	IEA
plasma membrane	TAS
external side of plasma membrane	IDA	18988804
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	24928897

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

delta protein

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 3** entries
InterPro
EGF-like calcium-binding domain
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8788	Xenbase:XB-GENE-988620	HUMAN21243
Xenopus tropicalis	13386	Xenbase:XB-GENE-988620
Rattus norvegicus	114587		RATNO36770
Pan troglodytes	467556		PANTR09551
Canis lupus familiaris	490860		CANLF18225
Monodelphis domestica	664656		MONDO08765
Macaca mulatta	707595		MACMU42581
Equus caballus	100054933		HORSE23269
Ornithorhynchus anatinus	100082485		ORNAN11879
Taeniopygia guttata	100224814		TAEGU25389

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements