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desmocollin 1

Summary

Gene Symbol

Dsc1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13505

PubChem

13505

Alliance of Genome Resources

MGI:109173

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q2VPA9
Q32ME9
P55849

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
desmosome maintenance	IMP	11714727
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
hair follicle morphogenesis	IMP	11714727
negative regulation of epithelial cell proliferation	IMP	11714727
establishment of skin barrier	IMP	11714727

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

desmosome maintenance

cell-cell junction organization [inference]

desmosome organization [inference]

desmosome maintenance

cell-cell junction maintenance [inference]

desmosome maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

desmosome maintenance

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

hair follicle morphogenesis

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
desmosome	IDA	14673151 38395410
desmosome	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IBA
calcium ion binding	IEA
protein binding	IPI	12847106 14673151

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

desmocollin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
sprouting angiogenesis

Displaying **all 8** entries
InterPro
Cadherin conserved site
Cadherin prodomain
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily
Desmosomal cadherin