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Guidelines

MIRAGE

carboxypeptidase A3

Summary

Gene Symbol

CPA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1359

PubChem

1359

Alliance of Genome Resources

HGNC:2298

Annotation

Keyword

Carboxypeptidase
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Metal-binding
Metalloprotease
Reference proteome
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P15088	Carboxypeptidase A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of angiotensin levels in blood
angiotensin maturation	IEA
proteolysis	TAS	2708524
proteolysis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of angiotensin levels in blood

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	HDA	27068509
extracellular space	IBA
transport vesicle	IEA
secretory granule	NAS	2594780

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metallocarboxypeptidase activity	NAS	2594780
metallocarboxypeptidase activity	TAS	1629626
metallocarboxypeptidase activity	IBA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxypeptidase T

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
carboxypeptidase activity
hydrolase activity
metal ion binding
metallocarboxypeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 3** entries
InterPro
Carboxypeptidase, activation peptide
Metallocarboxypeptidase-like, propeptide
Peptidase M14, carboxypeptidase A

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1359	Xenbase:XB-GENE-853724
Saccharomyces cerevisiae S288C	1361	SGD:S000001174
Mus musculus	12873	Xenbase:XB-GENE-853724	MOUSE38487
Saccharomyces cerevisiae S288C	51200	SGD:S000001174
Rattus norvegicus	54242		RATNO23178
Saccharomyces cerevisiae S288C	56373	SGD:S000001174
Saccharomyces cerevisiae S288C	57094	SGD:S000001174
Saccharomyces cerevisiae S288C	71791	SGD:S000001174
Saccharomyces cerevisiae S288C	74649	SGD:S000001174
Saccharomyces cerevisiae S288C	113936	SGD:S000001174

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025