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ectodysplasin-A

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13607

PubChem

13607

Alliance of Genome Resources

MGI:1195272

Annotation

Keyword

Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Collagen
Cytokine
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A0U5J8Q0
Q1L2D6
Q1L2D8
Q1L2E0
Q1L2D9
O54693	EDA protein homolog Tabby protein
Q3UV69

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
hair follicle development	IMP	18689798 544312
hair follicle development	IGI	18689798
immune response	IEA
cell-matrix adhesion	IDA	10534613
gene expression	IMP	17673451

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube lumen cavitation [inference]

salivary gland cavitation

ectodermal placode formation [inference]

hair follicle placode formation

anatomical structure development [inference]

hair follicle development

animal organ development

skin development

gland development [inference]

trachea gland development

cellular developmental process [inference]

cell differentiation

pigmentation

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
collagen trimer	IEA
extracellular space	IBA
extracellular space	IEA
endoplasmic reticulum membrane	IDA	10534613
lipid droplet	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular non-membrane-bounded organelle [inference]

lipid droplet

apical part of cell

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
death receptor binding	ISS
death receptor binding	ISO
cytokine activity	ISO
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

receptor ligand activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tumor necrosis factor

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
animal organ development
death receptor agonist activity
death receptor binding
immune response
tumor necrosis factor receptor binding

Displaying **all 2** entries
InterPro
Tumour necrosis factor domain
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14793	hypohidrotic ectodermal dysplasia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1896	Xenbase:XB-GENE-6462439	HUMAN101089
Drosophila melanogaster	8742	FB:FBgn0033483
Xenopus tropicalis	13607	Xenbase:XB-GENE-6462439
Drosophila melanogaster	21944	FB:FBgn0033483
Xenopus tropicalis	36054	Xenbase:XB-GENE-6462439
Rattus norvegicus	302424		RATNO45523
Drosophila melanogaster	407977	FB:FBgn0033483
Macaca mulatta	694110		MACMU47988
Oryctolagus cuniculus	100340021		RABIT13575
Callithrix jacchus	100406335		CALJA47044

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements