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eukaryotic translation elongation factor 2

Summary

Gene Symbol

Eef2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13629

PubChem

13629

Alliance of Genome Resources

MGI:95288

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Elongation factor
GTP-binding
Hydrolase
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P58252

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IMP	24029230
translational elongation	ISO
translational elongation	IDA	22157746
translational elongation	IBA
positive regulation of translation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

protein metabolic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

primary metabolic process [inference]

protein metabolic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

protein metabolic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

protein metabolic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

translation at synapse [inference]

translation at postsynapse

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

Displaying entries **16 - 17** of 17 in total

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GO Term	Evidence Code	PMID
ribonucleoprotein complex	ISO	18809582
ribonucleoprotein complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

membrane [inference]

plasma membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

ribosome

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
p53 binding	ISO
RNA binding	ISO
translation elongation factor activity	ISS
translation elongation factor activity	ISO
translation elongation factor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

p53 binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

actin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

rRNA binding [inference]

5S rRNA binding

lncRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation elongation factor activity

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation elongation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Elongation FacTor

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying entries **1 - 10** of 11 in total

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InterPro
EF-G domain III/V-like
Elongation Factor G, domain II
Elongation factor EFG, domain V-like
P-loop containing nucleoside triphosphate hydrolase
Ribosomal protein uS5 domain 2-type superfamily
Small GTP-binding protein domain
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Translation elongation factor EFG/EF2, domain IV
Translation elongation factor EFTu-like, domain 2
Translation protein, beta-barrel domain superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1938	Xenbase:XB-GENE-969739	HUMAN39819
Xenopus tropicalis	13629	Xenbase:XB-GENE-969739
Rattus norvegicus	29565		RATNO37637
Bos taurus	281138		BOVIN32901
Danio rerio	326929		DANRE28534
Canis lupus familiaris	476744		CANLF08023
Macaca mulatta	721806		MACMU20396
Monodelphis domestica	100022172		MONDO16984
Equus caballus	100061437		HORSE40027
Ornithorhynchus anatinus	100085359		ORNAN30366

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements