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MIRAGE

eukaryotic translation initiation factor 3, subunit A

Summary

Gene Symbol

Eif3a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13669

PubChem

13669

Alliance of Genome Resources

MGI:95301

Annotation

Keyword

Acetylation
Coiled coil
Cytoplasm
Cytoskeleton
Initiation factor
Nucleus
Phosphoprotein
RNA editing
RNA-binding
Reference proteome
Repeat

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3TRH1
Q3UM46	eIF3 p180 eIF3 p185
P23116	Centrosomin Eukaryotic translation initiation factor 3 subunit 10 eIF-3-theta eIF3 p167 eIF3 p180 eIF3 p185 p162

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
formation of cytoplasmic translation initiation complex	ISO
formation of cytoplasmic translation initiation complex	IDA	17581632
formation of cytoplasmic translation initiation complex	IBA
translation reinitiation	IBA
negative regulation of ERK1 and ERK2 cascade	ISO

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

translational initiation [inference]

cytoplasmic translational initiation [inference]

translation reinitiation

cellular process [inference]

cellular metabolic process [inference]

translational initiation [inference]

cytoplasmic translational initiation [inference]

translation reinitiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

viral process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
nucleolus	ISO
nucleolus	IEA
centrosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 3 complex

ribonucleoprotein complex [inference]

multi-eIF complex

translation preinitiation complex [inference]

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

postsynaptic specialization [inference]

postsynaptic density

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
RNA binding	ISO
RNA binding	IEA
mRNA binding	IBA
translation initiation factor activity	ISO
translation initiation factor activity	IDA	17581632

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
cytoplasmic translational initiation
formation of cytoplasmic translation initiation complex
translation reinitiation

Displaying **all 2** entries
InterPro
Eukaryotic translation initiation factor 3 subunit A
Proteasome component (PCI) domain

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025