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coproporphyrinogen oxidase

Summary

Gene Symbol

CPOX

Organism

Homo sapiens (human)

External Links

NCBI Gene

1371

PubChem

1371

Alliance of Genome Resources

HGNC:2321

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Heme biosynthesis
Hereditary hemolytic anemia
Mitochondrion
Oxidoreductase
Phosphoprotein
Porphyrin biosynthesis
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P36551

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protoporphyrinogen IX biosynthetic process	IBA
protoporphyrinogen IX biosynthetic process	IEA
heme biosynthetic process	TAS	8159699
heme A biosynthetic process	IEA
heme B biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
mitochondrion	IDA
mitochondrion	HTP	34800366
mitochondrial intermembrane space	TAS
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
coproporphyrinogen oxidase activity	IDA	7987309
coproporphyrinogen oxidase activity	IBA
structural constituent of eye lens	IEA
protein homodimerization activity	IDA	16176984

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [inference]

coproporphyrinogen oxidase activity

structural molecule activity [inference]

structural constituent of eye lens

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

coproporphyrinogen_III_oxidase

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
coproporphyrinogen oxidase activity
heme biosynthetic process
oxidoreductase activity
porphyrin-containing compound biosynthetic process
protoporphyrinogen IX biosynthetic process

Displaying **all 3** entries
InterPro
Coproporphyrinogen III oxidase, aerobic
Coproporphyrinogen III oxidase, conserved site
Oxygen-dependent coproporphyrinogen III oxidase superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:13269	hereditary coproporphyria	Alliance of Genome Resources
DOID:409	liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1371	Xenbase:XB-GENE-950297
Mus musculus	12892	Xenbase:XB-GENE-950297	MOUSE18262
Rattus norvegicus	304024		RATNO04434
Danio rerio	321294		DANRE43660
Pan troglodytes	460544		PANTR31674
Bos taurus	540283		BOVIN14378
Macaca mulatta	698849		MACMU29039
Monodelphis domestica	100031341		MONDO32046
Equus caballus	100072394		HORSE14644
Taeniopygia guttata	100221663		TAEGU10062

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Acknowledgements