GlyCosmos Portal

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GO Term	Evidence Code	PMID
carbamoyl-phosphate synthase (ammonia) activity	EXP	6249820
carbamoyl-phosphate synthase (ammonia) activity	IMP	8486760 9711878
carbamoyl-phosphate synthase (ammonia) activity	IBA
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	IBA
endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

carbamoyl-phosphate synthase (ammonia) activity

carbon-nitrogen ligase activity, with glutamine as amido-N-donor [inference]

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

amide binding [inference]

glutamate binding

small molecule binding

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

calcium ion binding

alkali metal ion binding [inference]

potassium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carbamoyl-phosphate synthase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 6** entries
Gene Ontology
'de novo' pyrimidine nucleobase biosynthetic process
ATP binding
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
glutamine metabolic process
ligase activity
nucleotide binding

Displaying **all 6** entries
InterPro
Carbamoyl-phosphate synthase small subunit, GATase1 domain
Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily
Carbamoyl-phosphate synthase small subunit, N-terminal domain
Carbamoyl-phosphate synthase, small subunit
Class I glutamine amidotransferase-like
Glutamine amidotransferase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:13042	persistent fetal circulation syndrome	Alliance of Genome Resources
DOID:178	vascular disease	Alliance of Genome Resources
DOID:9280	carbamoyl phosphate synthetase I deficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1373	Xenbase:XB-GENE-1010206
Mus musculus	227231	Xenbase:XB-GENE-1010206	MOUSE30015
Canis lupus familiaris	488506		CANLF14187
Rattus norvegicus	497840	Xenbase:XB-GENE-1010206	RATNO43569
Bos taurus	510506		BOVIN24687
Danio rerio	555623		DANRE44993
Pan troglodytes	738670		PANTR29681
Monodelphis domestica	100015090		MONDO32432
Equus caballus	100050116		HORSE37476
Ornithorhynchus anatinus	100077228		ORNAN24296

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements