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epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

Summary

Gene Symbol

Epm2a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13853

PubChem

13853

Alliance of Genome Resources

MGI:1341085

Annotation

Keyword

Autophagy
Cell membrane
Cytoplasm
Endoplasmic reticulum
Glycogen metabolism
Phosphoprotein
Protein phosphatase
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9WUA5	Glucan phosphatase Lafora PTPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 35 in total

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GO Term	Evidence Code	PMID
negative regulation of dephosphorylation	ISO
regulation of protein kinase activity	IMP	24914213
nervous system development	IMP	12019206
negative regulation of gene expression	IMP	18824542
glycogen metabolic process	IGI IMP ISO ISS	18852261 21552327 23663739 24914213 25416783 28973665

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

dephosphorylation

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate phosphorylation

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate phosphorylation

macromolecule metabolic process

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cell population proliferation [inference]

glial cell proliferation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

dephosphorylation

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

habituation

behavior [inference]

learning or memory [inference]

learning [inference]

nonassociative learning [inference]

habituation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic substance transport [inference]

calcium ion transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity

negative regulation of dephosphorylation

negative regulation of phosphatase activity

regulation of phosphorylation

regulation of protein phosphorylation

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of kinase activity [inference]

regulation of protein kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein modification process [inference]

regulation of protein phosphorylation

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell cycle

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity

negative regulation of dephosphorylation

negative regulation of phosphatase activity

regulation of phosphorylation

regulation of protein phosphorylation

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of peptidyl-serine phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of protein kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

regulation of kinase activity [inference]

regulation of protein kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation

negative regulation of phosphatase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of peptidyl-serine phosphorylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell cycle

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell cycle [inference]

negative regulation of cell cycle

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity

regulation of ubiquitin-protein transferase activity [inference]

regulation of ubiquitin protein ligase activity

regulation of glycogen (starch) synthase activity

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16959610 22578008 28063983
protein tyrosine/serine/threonine phosphatase activity	TAS	12019206
starch binding	IDA	15102711
protein tyrosine phosphatase activity	IBA IDA ISO	15541350
carbohydrate phosphatase activity	IDA IMP ISO ISS	18040046

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

glycogen (starch) synthase activity

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

UDP-glucosyltransferase activity [inference]

glycogen (starch) synthase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

myosin phosphatase activity

carbohydrate phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

myosin phosphatase activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity

protein homodimerization activity

carbohydrate binding

polysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Laforin

Functional Category

K: Transcription
L: Replication, recombination and repair
P: Inorganic ion transport and metabolism

Displaying **all 7** entries
Gene Ontology
carbohydrate phosphatase activity
dephosphorylation
glucan metabolic process
hydrolase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity

Displaying **all 7** entries
InterPro
Dual specificity phosphatase, catalytic domain
Dual specificity protein phosphatase domain
Laforin-like, dual specificity phosphatase domain
Laforin
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatases domain

Rhea

RHEA:20629

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:47004

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:10684

H₂O

phosphate

Enzyme

3.1.3.48

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3534	Lafora disease	Alliance of Genome Resources
DOID:891	progressive myoclonus epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **100** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Onychomys torridus	118570718	38674_0:00440f
Balaenoptera musculus	118905237		BALMU27021
Arvicola amphibius	119821289	1047088_0:003054
Microtus oregoni	121466603	111838_0:0041a3
Dipodomys spectabilis	122111962	105255_0:00002e
Panthera leo	122220465		PANLE16311
Ursus americanus	123797413		URSAM23179
Marmota monax	124096854	9995_0:000211
Sciurus carolinensis	124989095	30640_0:0025e6
Perognathus longimembris pacificus	125357371	214514_0:0025f9

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements