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erb-b2 receptor tyrosine kinase 3

Summary

Gene Symbol

Erbb3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13867

PubChem

13867

Alliance of Genome Resources

MGI:95411

Annotation

Keyword

ATP-binding
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61526	Glial growth factor receptor Proto-oncogene-like protein c-ErbB-3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
endocardial cushion development	IMP	9362461
protein phosphorylation
negative regulation of cell adhesion	ISO
negative regulation of cell adhesion	IEA
signal transduction	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

motor neuron apoptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

neuron differentiation

cell development [inference]

glial cell development [inference]

Schwann cell development

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

mesenchyme development [inference]

endocardial cushion development

nerve development [inference]

cranial nerve development

cell development [inference]

glial cell development [inference]

Schwann cell development

system development [inference]

peripheral nervous system development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

Schwann cell differentiation

neuron differentiation

cell development [inference]

glial cell development [inference]

Schwann cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of signaling [inference]

negative regulation of signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

regulation of glucose import [inference]

positive regulation of glucose import

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

regulation of secretion [inference]

negative regulation of secretion

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

negative regulation of transport [inference]

negative regulation of secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of multicellular organismal process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of transport [inference]

negative regulation of secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of developmental process [inference]

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

regulation of cardiac muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

regulation of cardiac muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

ERBB3 signaling pathway [inference]

ERBB2-ERBB3 signaling pathway

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

signal transduction in absence of ligand [inference]

extrinsic apoptotic signaling pathway in absence of ligand

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway in absence of ligand

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

regulation of calcineurin-mediated signaling [inference]

regulation of calcineurin-NFAT signaling cascade [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

regulation of glucose import [inference]

positive regulation of glucose import

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

regulation of cell population proliferation

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of calcium-mediated signaling [inference]

positive regulation of calcineurin-mediated signaling [inference]

positive regulation of calcineurin-NFAT signaling cascade

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport [inference]

positive regulation of glucose import

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of motor neuron apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of cardiac muscle tissue development

regulation of biological quality [inference]

regulation of membrane permeability [inference]

positive regulation of membrane permeability

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IEA
plasma membrane	IDA	8702723 9742126
plasma membrane	IBA
basal plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

ERBB3:ERBB2 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

ERBB3:ERBB2 complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

lateral plasma membrane

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
protein tyrosine kinase activity	ISO
transmembrane signaling receptor activity	IDA	9742126
protein binding	IPI	11276227 20639901 23897819
ATP binding	IEA
growth factor binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

ErbB-3 class receptor binding

growth factor binding

neuregulin binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

neuregulin receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tyrosine-protein kinase receptor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
ATP binding
kinase activity
neurogenesis
nucleotide binding
phosphorylation
positive regulation of cell population proliferation
transferase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

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InterPro
Furin-like cysteine-rich domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
Growth factor receptor domain 4
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Receptor L-domain superfamily
Receptor L-domain
Serine-threonine/tyrosine-protein kinase, catalytic domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements