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diacylglycerol kinase kappa

Summary

Gene Symbol

DGKK

Organism

Homo sapiens (human)

External Links

NCBI Gene

139189

HGNC

32395

KEGG Gene ID

hsa:139189

PubChem

139189

Alliance of Genome Resources

HGNC:32395

Annotation

Keyword

ATP-binding
Cell membrane
Kinase
Lipid metabolism
Phosphoprotein
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5KSL6	142 kDa diacylglycerol kinase Diglyceride kinase kappa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
phosphatidic acid biosynthetic process	IBA
intracellular signal transduction	IBA IDA	16210324

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phosphorylation [inference]

lipid phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular process [inference]

cell activation [inference]

platelet activation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

protein kinase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phosphorylation [inference]

lipid phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid modification [inference]

lipid phosphorylation

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

multicellular organismal process [inference]

cell activation [inference]

platelet activation

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

protein kinase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	16210324

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ATP-dependent diacylglycerol kinase activity	IBA IDA TAS	16210324
metal ion binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

ATP-dependent diacylglycerol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

ATP-dependent diacylglycerol kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00901

Name

diacylglycerol kinase (ATP) [EC:2.7.1.107]

References

Rhea

a 1,2-diacyl-sn-glycerol + ATP

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.7.1.107

PMID

15939762

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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2

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DO ID	Disease Name	Source
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:10892	hypospadias	DisGeNET
DOID:12995	conduct disorder	DisGeNET
DOID:13515	tuberous sclerosis	DisGeNET
DOID:14261	fragile X syndrome	DisGeNET
DOID:14323	Marfan syndrome	DisGeNET
DOID:150	disease of mental health	DisGeNET
DOID:1936	atherosclerosis	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001710
Gene Name: diacylglycerol kinase, kappa

Ortholog

Displaying entries **11 - 20** of 31 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gorilla gorilla gorilla	101139329		GORGO43678
Pan paniscus	100973217		PANPA41378
Pan troglodytes	473607		PANTR46013
Pongo abelii	100439951		PONAB36900
Mustela putorius furo	101672333		MUSPF12470
Felis catus	101085603		FELCA40033
Equus caballus	100063191		HORSE43278
Sus scrofa	100155983		PIGXX37337
Ovis aries	101110739		SHEEP19741
Dipodomys ordii	105997820		DIPOR21480

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024