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Guidelines

MIRAGE

CRK proto-oncogene, adaptor protein

Summary

Gene Symbol

CRK

Organism

Homo sapiens (human)

External Links

NCBI Gene

1398

PubChem

1398

Alliance of Genome Resources

HGNC:2362

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Phosphoprotein
Proto-oncogene
Reference proteome
Repeat
SH2 domain
SH3 domain

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P46108	Proto-oncogene c-Crk p38
A0A0S2Z3Q4
A0A0S2Z3K9
L7RT18

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 49 in total

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GO Term	Evidence Code	PMID
cell migration	IBA
hippocampus development	IEA
cerebral cortex development	IEA
establishment of cell polarity	IEA
actin cytoskeleton organization	IMP	31311869

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

diapedesis [inference]

helper T cell diapedesis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

helper T cell diapedesis

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

reelin-mediated signaling pathway

cell population proliferation

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

cerebellar neuron development

cell motility [inference]

neuron migration

leukocyte migration [inference]

diapedesis [inference]

helper T cell diapedesis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration [inference]

helper T cell diapedesis

cell chemotaxis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

organelle assembly [inference]

postsynaptic specialization assembly

postsynaptic specialization organization [inference]

postsynaptic specialization assembly

cellular component assembly [inference]

organelle assembly [inference]

postsynaptic specialization assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

cerebellar neuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

cerebellar neuron development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to fungus [inference]

response to yeast

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

response to peptide hormone [inference]

response to cholecystokinin

cellular response to peptide hormone stimulus [inference]

response to endothelin [inference]

cellular response to endothelin

response to growth factor [inference]

response to hepatocyte growth factor

cellular response to growth factor stimulus [inference]

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

response to peptide hormone [inference]

response to cholecystokinin

cellular response to peptide hormone stimulus [inference]

response to endothelin [inference]

cellular response to endothelin

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to peptide

response to peptide hormone [inference]

response to cholecystokinin

cellular response to peptide hormone stimulus [inference]

response to endothelin [inference]

cellular response to endothelin

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to hydrogen peroxide

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to inorganic substance [inference]

response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to nitric oxide

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to peptide

response to peptide hormone [inference]

response to cholecystokinin

cellular response to peptide hormone stimulus [inference]

response to endothelin [inference]

cellular response to endothelin

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to nitric oxide [inference]

cellular response to nitric oxide

response to peptide

response to peptide hormone [inference]

response to cholecystokinin

cellular response to peptide hormone stimulus [inference]

response to endothelin [inference]

cellular response to endothelin

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to peptide [inference]

cellular response to peptide hormone stimulus [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of cell motility

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cell motility

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell growth

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of locomotion [inference]

negative regulation of cell motility

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cell motility

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of wound healing

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to wounding [inference]

negative regulation of wound healing

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of wound healing

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of wound healing

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to wounding [inference]

negative regulation of wound healing

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of response to wounding [inference]

regulation of wound healing

negative regulation of wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of dendrite development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

reelin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of cell adhesion mediated by integrin

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell growth

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cell motility

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of protein localization to membrane [inference]

positive regulation of receptor clustering [inference]

positive regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade [inference]

positive regulation of JNK cascade

regulation of cell motility

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of mononuclear cell migration [inference]

regulation of lymphocyte migration [inference]

regulation of T cell migration

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cell motility

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of biological quality [inference]

regulation of cell shape

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of GTPase activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	TAS	10748058
cytoplasm	IC	11870224
cytoplasm	IBA
cytosol	TAS
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

plasma membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
phosphotyrosine residue binding	IPI	20624904
insulin-like growth factor receptor binding	IEA
protein binding	IPI	10733900 11316748 12384576 12799422 12878163 14657239 15886098 16189514 16273093 16713569 17038317 17474147 17515907 18722344 19001122 19004829 19380743 19447967 20534451 21044950 21988832 23275563 24658140 24728074 25241761 25416956 25544563 25814554 26656091 26871637 27107012 28086240 31311869 31980649 32296183 32814053 33961781 35044719 7561682 8524328 8626543 9472046 9546424 9788432
cytoskeletal protein binding	IEA
SH3 domain binding	IPI	12384576

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytoskeletal protein binding

enzyme binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

receptor tyrosine kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein domain specific binding [inference]

phosphoprotein binding [inference]

protein phosphorylated amino acid binding

phosphotyrosine residue binding

scaffold protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

signaling receptor complex adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CRK

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell migration
receptor tyrosine kinase binding
signaling adaptor activity

Displaying **all 5** entries
InterPro
CRK, N-terminal SH3 domain
SH2 domain superfamily
SH2 domain
SH3 domain
SH3-like domain superfamily

Ortholog

Displaying entries **31 - 40** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Chinchilla lanigera	102022192		CHILA18176
Capra hircus	102174330		CAPHI10173
Latimeria chalumnae	102350481		LATCH05932
Myotis lucifugus	102440736		MYOLU11612
Pelodiscus sinensis	102457830		PELSI00727
Vicugna pacos	102539935		VICPA08117
Neolamprologus brichardi	102790434		NEOBR05100
Astyanax mexicanus	103035530		ASTMX04408
Poecilia formosa	103145511		POEFO12058
Chlorocebus sabaeus	103242119		CHLSB05054

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025