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Guidelines

MIRAGE

protein O-fucosyltransferase 1

Summary

Gene Symbol

Pofut1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

140484

KEGG Gene ID

mmu:140484

PubChem

140484

Alliance of Genome Resources

MGI:2153207

Annotation

Keyword

3D-structure
Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Manganese
Notch signaling pathway
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91ZW2	Peptide-O-fucosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
angiogenesis	IMP	12697902
somitogenesis	IMP	12697902
fucose metabolic process	TAS	11524432
protein O-linked glycosylation	ISS
protein O-linked glycosylation	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein O-linked fucosylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum	IBA
endoplasmic reticulum	IEA
membrane	ISS
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fucosyltransferase activity	ISS	11524432
fucosyltransferase activity	ISO	11524432
peptide-O-fucosyltransferase activity	ISO
peptide-O-fucosyltransferase activity	IBA
peptide-O-fucosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

GDP-fucose protein O-fucosyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 5** entries
Gene Ontology
fucose metabolic process
peptide-O-fucosyltransferase activity
protein O-linked fucosylation
regulation of Notch signaling pathway
transferase activity

Displaying **all 2** entries
InterPro
GDP-fucose protein O-fucosyltransferase 1
GDP-fucose protein O-fucosyltransferase

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Ortholog

Displaying entries **61 - 70** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sinocyclocheilus grahami	107558235		SINGR81379
Ictalurus punctatus	108276463		ICTPU07657
Rhinopithecus bieti	108524134		RHIBE32984
Cyprinus carpio carpio	109048071		CYPCA118179
Crocodylus porosus	109313092		CROPO22416
Phascolarctos cinereus	110211428		PHACI10289
Vulpes vulpes	112909907		VULVU36131
Pseudonaja textilis	113451383		PSETE25451
Bos indicus x Bos taurus	113903137		BOBOX02383
Vombatus ursinus	114047329		VOMUR05324

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025