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ATP binding cassette subfamily C member 3

Summary

Gene Symbol

Abcc3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

140668

PubChem

140668

Alliance of Genome Resources

RGD:71101

Annotation

Keyword

ATP-binding
Cell membrane
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O88563	Canalicular multispecific organic anion transporter 2 MRP-like protein 2 Multidrug resistance-associated protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	ISO
xenobiotic transmembrane transport	IEA
response to organic cyclic compound
bile acid and bile salt transport	IMP	10644759
canalicular bile acid transport	IDA	10362653

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound

response to estradiol

response to lipid [inference]

response to tetrachloromethane

response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

xenobiotic transport

xenobiotic transmembrane transport

secretion [inference]

canalicular bile acid transport

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

icosanoid transport [inference]

leukotriene transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

icosanoid transport [inference]

leukotriene transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

carbohydrate derivative transport [inference]

glycoside transport [inference]

glucuronoside transport

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IDA	18698235
plasma membrane	IEA
basal plasma membrane	ISO
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

membrane

plasma membrane

plasma membrane region [inference]

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
ABC-type xenobiotic transporter activity	ISO
ABC-type xenobiotic transporter activity	IEA
glucuronoside transmembrane transporter activity	ISO
glucuronoside transmembrane transporter activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

icosanoid transmembrane transporter activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity [inference]

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

icosanoid transmembrane transporter activity

carbohydrate derivative transmembrane transporter activity [inference]

glucuronoside transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
basolateral plasma membrane	PMID:12909565

Ortholog

Displaying entries **31 - 40** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Cavia porcellus	100713825	CAVPO17318
Cricetulus griseus	100767558	CRIGR08664
Sarcophilus harrisii	100930098	SARHA17906
Papio anubis	101014971	PAPAN14242
Saimiri boliviensis boliviensis	101034966	SAIBB18841
Takifugu rubripes	101069870	TAKRU24328
Ovis aries	101116746	SHEEP02909
Gorilla gorilla gorilla	101145190	GORGO33416
Oryzias latipes	101175305	ORYLA19764
Tursiops truncatus	101329249	TURTR11184