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adaptor related protein complex 2 subunit beta 1

Summary

Gene Symbol

Ap2b1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

140670

PubChem

140670

Alliance of Genome Resources

RGD:71048

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Coated pit
Endocytosis
Membrane
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6HHH4
Q3ZB97
P62944	AP105B Adaptor protein complex AP-2 subunit beta Adaptor-related protein complex 2 subunit beta Beta-2-adaptin Beta-adaptin Clathrin assembly protein complex 2 beta large chain Plasma membrane adaptor HA2/AP2 adaptin beta subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of protein localization to membrane	IMP	19240038
heart development	ISO
neurotransmitter receptor internalization	ISO
postsynaptic neurotransmitter receptor internalization	EXP IDA IMP ISO NAS	17289840
vesicle-mediated transport	IBA IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

developmental process [inference]

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

coronary vasculature development

cardiac septum development

ventricular septum development

animal organ development [inference]

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization

postsynaptic neurotransmitter receptor internalization

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane

regulation of protein localization to membrane [inference]

positive regulation of protein localization to membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to membrane

regulation of protein localization to membrane [inference]

positive regulation of protein localization to membrane

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

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GO Term	Evidence Code	PMID
AP-type membrane coat adaptor complex	TAS	8262066
endomembrane system	IEA
synapse	ISO
synaptic vesicle	EXP IDA	33376223
glutamatergic synapse	EXP IDA IMP ISO NAS	17289840

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat

AP-type membrane coat adaptor complex

clathrin adaptor complex

AP-2 adaptor complex

plasma membrane protein complex [inference]

AP-2 adaptor complex

cellular anatomical entity [inference]

endomembrane system

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of presynaptic membrane [inference]

extrinsic component of presynaptic endocytic zone membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

postsynaptic endocytic zone

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10428863 17022975
protein-containing complex binding	IPI	12297494
clathrin binding	IBA IDA IEA ISO	8262066

GO Hierarchy

molecular function

binding [inference]

protein binding

clathrin binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

AP-2 complex subunit beta

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
clathrin binding

Displaying entries **11 - 12** of 12 in total

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InterPro
Coatomer/calthrin adaptor appendage, C-terminal subdomain
TBP domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **127** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	163		HGNC:563	HUMAN33042
Drosophila melanogaster	32987		FB:FBgn0010380
Mus musculus	71770	10090_1:003af6	MGI:1919020	MOUSE05694
Caenorhabditis elegans	175376		WB:WBGene00000160
Bos taurus	282183			BOVIN12274
Danio rerio	334632		ZFIN:ZDB-GENE-030131-6564	DANRE36307
Xenopus tropicalis	394814		Xenbase:XB-GENE-5871354
Pan troglodytes	454587			PANTR14237
Canis lupus familiaris	480605			CANLF19014
Saccharomyces cerevisiae S288C	853461		SGD:S000003765