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dynamin 1

Summary

Gene Symbol

Dnm1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

140694

PubChem

140694

Alliance of Genome Resources

RGD:71096

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Coated pit
Cytoplasmic vesicle
Direct protein sequencing
Endocytosis
GTP-binding
Golgi apparatus
Hydrolase
Methylation
Microtubule
Motor protein
Nitration
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
P21575	B-dynamin D100 Dynamin I Dynamin, brain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 32 in total

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GO Term	Evidence Code	PMID
regulation of vesicle size	ISO
regulation of vesicle size	IEA
clathrin coat assembly involved in endocytosis	ISS
clathrin coat assembly involved in endocytosis	ISO
clathrin coat assembly involved in endocytosis	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

G protein-coupled receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle budding from membrane [inference]

synaptic vesicle budding [inference]

synaptic vesicle budding from presynaptic endocytic zone membrane

endosome organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly [inference]

clathrin coat assembly involved in endocytosis

protein complex oligomerization [inference]

protein homooligomerization

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of vesicle size

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly [inference]

clathrin coat assembly involved in endocytosis

protein complex oligomerization [inference]

protein homooligomerization

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

membrane organization [inference]

vesicle budding from membrane [inference]

synaptic vesicle budding [inference]

synaptic vesicle budding from presynaptic endocytic zone membrane

membrane fission [inference]

vesicle scission

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

response to amyloid-beta

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

G protein-coupled receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

G protein-coupled receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling

positive regulation of synaptic vesicle endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling

positive regulation of synaptic vesicle endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling

positive regulation of synaptic vesicle endocytosis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of vesicle size

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
photoreceptor inner segment	ISO
photoreceptor inner segment	IEA
cytoplasm	IBA
Golgi apparatus	IDA	9725914
Golgi apparatus	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

membrane coat

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

synaptic membrane [inference]

presynaptic endocytic zone membrane

cell junction [inference]

synapse

ribbon synapse [inference]

photoreceptor ribbon synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

varicosity

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle

endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

exocytic vesicle [inference]

synaptic vesicle

presynapse

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
GTPase activity	ISS
GTPase activity	ISO
GTPase activity	TAS
GTPase activity	IBA
GTPase activity	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

GTPase motor activity [inference]

membrane scission GTPase motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

GTPase motor activity [inference]

membrane scission GTPase motor activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D2 dopamine receptor binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein serine/threonine kinase binding

nitric-oxide synthase binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dynamin

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
GTP binding
microtubule binding
nucleotide binding

Displaying **all 9** entries
InterPro
Dynamin GTPase effector
Dynamin stalk domain
Dynamin, GTPase domain
Dynamin, GTPase region, conserved site
Dynamin, N-terminal
Dynamin-type guanine nucleotide-binding (G) domain
Dynamin
GTPase effector domain
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
synaptic vesicle	PMID:12646135
varicosity	PMID:12646135
protein-containing complex	PMID:17257598

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1759	Xenbase:XB-GENE-986845	HUMAN98664
Saccharomyces cerevisiae S288C	1785	SGD:S000001709
Mus musculus	13429	Xenbase:XB-GENE-986845	MOUSE34155
Saccharomyces cerevisiae S288C	13430	SGD:S000001709
Saccharomyces cerevisiae S288C	103967	SGD:S000001709
Xenopus tropicalis	140694	Xenbase:XB-GENE-986845
Canis lupus familiaris	491319		CANLF19406
Bos taurus	508794		BOVIN03218
Felis catus	654421		FELCA30659
Macaca mulatta	717697		MACMU12812

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements