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MIRAGE
transient receptor potential cation channel subfamily M member 6

Summary
Gene Symbol
  • TRPM6
Organism
Homo sapiens (human)
NCBI Gene
140803
PubChem
140803
Alliance of Genome Resources
Annotation
Keyword
  • ATP-binding
  • Alternative splicing
  • Calcium channel
  • Cell membrane
  • Disease variant
  • Metal-binding
  • Phosphoprotein
  • Primary hypomagnesemia
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transmembrane helix
  • Zinc
Proteins
Displaying 1 entry
UniProt Protein Name
Q9BX84
  • Channel kinase 2
  • Melastatin-related TRP cation channel 6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
chromatin remodeling
protein phosphorylation
response to toxic substance
metal ion transport
protein tetramerization
GO Hierarchy
Displaying entries 1 - 5 of 29 in total
GO Term Evidence Code PMID
protein serine/threonine kinase activity
3-phosphoinositide-dependent protein kinase activity
DNA-dependent protein kinase activity
AMP-activated protein kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
transient receptor potential cation channel subfamily m member 7
Functional Category
  • E: Amino acid transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • P: Inorganic ion transport and metabolism
  • T: Signal transduction mechanisms
Displaying entries 1 - 10 of 11 in total
Gene Ontology
ATP binding
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
kinase activity
metal ion binding
monoatomic ion channel activity
monoatomic ion transport
phosphorylation
protein tetramerization
Displaying all 6 entries
InterPro
Alpha-type protein kinase, alpha-kinase domain
Ion transport domain
Protein kinase-like domain superfamily
TRPM, SLOG domain
TRPM, tetramerisation domain superfamily
TRPM, tetramerisation domain
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:0060883 intestinal hypomagnesemia 1
DOID:896 metal metabolism disorder
Ortholog
Displaying entries 1 - 10 of 54 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
4308 FB:FBgn0265194
17364 FB:FBgn0265194
80036 FB:FBgn0265194
140803 Xenbase:XB-GENE-958179
225997 MOUSE26590
293874 RATNO20139
361586 FB:FBgn0265194
472957 PANTR44127
484163 CANLF00422
706119 MACMU12643
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025