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FAT atypical cadherin 1

Summary

Gene Symbol

Fat1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14107

PubChem

14107

Alliance of Genome Resources

MGI:109168

Annotation

Keyword

Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A087WRT4
F2Z4A3
A0A1L1SQU7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
lens development in camera-type eye	IMP	26114487
epithelial cell morphogenesis	IMP	26114487
establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis	IMP	26114487
actin filament organization	IMP	15148305
homophilic cell adhesion via plasma membrane adhesion molecules

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

establishment or maintenance of cell polarity

establishment of cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

establishment of epithelial cell polarity [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

establishment or maintenance of epithelial cell apical/basal polarity

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity [inference]

establishment of apical/basal cell polarity [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

camera-type eye morphogenesis

anatomical structure development [inference]

lens development in camera-type eye

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

polarized epithelial cell differentiation [inference]

establishment of epithelial cell apical/basal polarity [inference]

establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
cytosol	ISO
plasma membrane	ISO
plasma membrane	IDA	26114487
cell-cell junction	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding
protein binding	IPI	15148305

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protocadherin Fat

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
cadherin binding
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 8** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Cadherin
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like domain
Laminin G domain