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SLIT-ROBO Rho GTPase activating protein 2

Summary

Gene Symbol

Srgap2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14270

PubChem

14270

Alliance of Genome Resources

MGI:109605

Annotation

Keyword

Cell membrane
Cell projection
Coiled coil
Cytoplasm
Cytoplasmic vesicle
GTPase activation
Methylation
Neurogenesis
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
SH3 domain

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91Z67	Formin-binding protein 2 Formin-binding protein 27

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of synapse assembly	IDA IMP	22559944
filopodium assembly	IDA	19737524
signal transduction	IEA
actin filament severing	ISS
substrate adhesion-dependent cell spreading

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction

actin filament-based process [inference]

actin filament severing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction assembly [inference]

synapse assembly [inference]

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

pseudopodium organization [inference]

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

lamellipodium organization [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synapse organization [inference]

synapse assembly [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

dendritic spine development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular process [inference]

signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	IEA ISO
lamellipodium	IEA ISO
postsynaptic membrane	IDA	22559944
glutamatergic synapse	IDA IMP ISO	22559944
phagocytic vesicle	IDA	21148482

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

postsynaptic specialization [inference]

postsynaptic density

dendritic spine head

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein heterodimerization activity	ISO
protein binding	IPI	8605874
small GTPase binding	IDA ISO	19737524
identical protein binding	ISO
protein homodimerization activity	IDA ISO	19737524

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	393	WB:WBGene00006406
Caenorhabditis elegans	9901	WB:WBGene00006406
Xenopus tropicalis	14270	Xenbase:XB-GENE-5897849
Homo sapiens	23380	Xenbase:XB-GENE-5897849	HUMAN54446
Caenorhabditis elegans	57522	WB:WBGene00006406
Caenorhabditis elegans	117600	WB:WBGene00006406
Caenorhabditis elegans	259302	WB:WBGene00006406
Rattus norvegicus	360840		RATNO06702
Pan troglodytes	457680		PANTR23512
Canis lupus familiaris	478949		CANLF14325