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SLIT-ROBO Rho GTPase activating protein 2

Summary

Gene Symbol

Srgap2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14270

PubChem

14270

Alliance of Genome Resources

MGI:109605

Annotation

Keyword

Cell membrane
Cell projection
Coiled coil
Cytoplasm
Cytoplasmic vesicle
GTPase activation
Methylation
Neurogenesis
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
SH3 domain

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91Z67	Formin-binding protein 2 Formin-binding protein 27

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lamellipodium assembly involved in ameboidal cell migration
signal transduction	IEA
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	IMP	19737524
regulation of cell migration	IDA	26439400
negative regulation of cell migration	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction

actin filament-based process [inference]

actin filament severing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction assembly [inference]

synapse assembly [inference]

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

pseudopodium organization [inference]

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

lamellipodium organization [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly [inference]

lamellipodium assembly involved in ameboidal cell migration

pseudopodium assembly [inference]

extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synapse organization [inference]

synapse assembly [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

dendritic spine development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular process [inference]

signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration

negative regulation of cell migration

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of neuron migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
cytosol	IDA	21148482
plasma membrane	ISO
plasma membrane	IDA	19737524
postsynaptic density	IDA	22559944
lamellipodium	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

postsynaptic specialization [inference]

postsynaptic density

dendritic spine head

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	ISO
GTPase activator activity	IDA	19737524 26439400
protein binding	IPI	8605874
small GTPase binding	ISO
small GTPase binding	IDA	19737524

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **41 - 50** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Cyprinus carpio carpio	109083865	CYPCA119381
Cyprinus carpio carpio	109087963	CYPCA124031
Crocodylus porosus	109317719	CROPO23847
Phascolarctos cinereus	110219575	PHACI09765
Vulpes vulpes	112914366	VULVU05814
Pseudonaja textilis	113446141	PSETE19199
Bos indicus x Bos taurus	113906332	BOBOX05833
Podarcis muralis	114599323	PODMU04726
Echeneis naucrates	115043105	ECHNA05134
Salmo trutta	115150900	SALTR34429