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folate receptor alpha

Summary

Gene Symbol

Folr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14275

PubChem

14275

Alliance of Genome Resources

MGI:95568

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Disulfide bond
Endosome
Folate-binding
GPI-anchor
Receptor
Reference proteome
Secreted
Signal
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
P35846	Folate receptor 1 Folate-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
folic acid transport	ISO ISS
response to axon injury	IMP	20424322
cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	17286298
neural crest cell migration involved in heart formation	IMP	17286298
folic acid metabolic process	IMP	12854656

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

folic acid metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

folic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cell adhesion

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration [inference]

cell migration involved in heart development [inference]

cardiac neural crest cell migration involved in outflow tract morphogenesis

cell migration involved in heart formation [inference]

neural crest cell migration involved in heart formation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to oxygen-containing compound [inference]

cellular response to folic acid

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development [inference]

axon regeneration

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

sperm-egg recognition

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

pharyngeal arch artery morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

anterior neural tube closure

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

response to vitamin [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to folic acid

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

response to vitamin [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to vitamin [inference]

cellular response to folic acid

response to organic substance [inference]

response to organonitrogen compound [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

response to organic cyclic compound [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to organic cyclic compound [inference]

cellular response to folic acid

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to oxygen-containing compound [inference]

cellular response to folic acid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to folic acid

response to oxygen-containing compound [inference]

response to folic acid [inference]

cellular response to folic acid

cellular response to oxygen-containing compound [inference]

cellular response to folic acid

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to folic acid

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to folic acid

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to folic acid

cellular response to oxygen-containing compound [inference]

cellular response to folic acid

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

transport [inference]

vitamin transport [inference]

folic acid transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

modified amino acid transport [inference]

folic acid transport

nitrogen compound transport [inference]

amide transport [inference]

folic acid transport

modified amino acid transport [inference]

folic acid transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA ISO ISS
membrane	TAS	11111049
apical plasma membrane	IEA ISO
clathrin-coated vesicle	IEA
endosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

coated vesicle [inference]

clathrin-coated vesicle

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor activity	IBA TAS	11111049
folic acid receptor activity	ISO ISS TAS	11111049
folic acid binding	ISO ISS TAS	11111049

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

cargo receptor activity [inference]

folic acid receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Folate receptor

Functional Category

K: Transcription
L: Replication, recombination and repair
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
fusion of sperm to egg plasma membrane involved in single fertilization
sperm-egg recognition

Displaying **all 2** entries
InterPro
Folate receptor-like
Folate receptor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050719	cerebral folate receptor alpha deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 100** of **112** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Arvicanthis niloticus	117714148	61156_0:00065a
Scophthalmus maximus	118299701		SCOMX22616
Onychomys torridus	118570044	38674_0:000791
Balaenoptera musculus	118898716		BALMU08671
Arvicola amphibius	119827170	1047088_0:00084c
Microtus oregoni	121463906	111838_0:003ac0
Dipodomys spectabilis	122115723	105255_0:000429
Panthera leo	122199719		PANLE14690
Ursus americanus	123782547		URSAM29937
Marmota monax	124091192	9995_0:00099e

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OrthoDB (Group)

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Acknowledgements