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MAGUK p55 scaffold protein 7

Summary

Gene Symbol

MPP7

Organism

Homo sapiens (human)

External Links

NCBI Gene

143098

PubChem

143098

Alliance of Genome Resources

HGNC:26542

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Tight junction

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5T2T1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
establishment of cell polarity	TAS	17332497
positive regulation of protein-containing complex assembly	TAS	14719143
positive regulation of protein-containing complex assembly	IDA	17237226
bicellular tight junction assembly	IDA	17332497
protein localization to adherens junction	IMP	17237226

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction [inference]

protein localization to adherens junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction [inference]

protein localization to adherens junction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction [inference]

protein localization to adherens junction

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
plasma membrane	IBA
cell-cell junction	IBA
adherens junction	IDA	17237226
bicellular tight junction	IDA	17332497

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MPP7-DLG1-LIN7 complex

cellular anatomical entity [inference]

nucleoplasm

cytoplasm [inference]

cell cortex

membrane [inference]

plasma membrane

lateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction

adherens junction

tight junction [inference]

bicellular tight junction

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GO Term	Evidence Code	PMID
molecular adaptor activity	IDA	17237226 20702775

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

cell adhesion molecule binding [inference]

cadherin binding

molecular adaptor activity

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

MAGUK p55 subfamily member

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

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InterPro
Guanylate kinase, conserved site
Guanylate kinase-like domain
Guanylate kinase/L-type calcium channel beta subunit
L27 domain superfamily
L27 domain, C-terminal
L27 domain
P-loop containing nucleoside triphosphate hydrolase
PDZ domain
PDZ superfamily
SH3 domain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	30166		DANRE03925
Drosophila melanogaster	58538	FB:FBgn0050021
Mus musculus	75739		MOUSE24789
Xenopus tropicalis	143098	Xenbase:XB-GENE-950404
Rattus norvegicus	307035		RATNO13168
Pan troglodytes	450377		PANTR00376
Canis lupus familiaris	487080		CANLF06517
Bos taurus	512659		BOVIN04517
Macaca mulatta	709246		MACMU44978
Monodelphis domestica	100024668		MONDO34722