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frizzled class receptor 3

Summary

Gene Symbol

Fzd3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14365

PubChem

14365

Alliance of Genome Resources

MGI:108476

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Neurogenesis
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61086

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **21 - 21** of 21 in total

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GO Term	Evidence Code	PMID
neural tube closure	IGI	16495441

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

canonical Wnt signaling pathway

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

cell proliferation in midbrain

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

post-anal tail morphogenesis

embryonic morphogenesis [inference]

inner ear morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

hair follicle development

tissue development [inference]

ganglion development [inference]

sympathetic ganglion development

midbrain development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

canonical Wnt signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle, embryonic [inference]

negative regulation of mitotic cell cycle, embryonic

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of execution phase of apoptosis [inference]

negative regulation of execution phase of apoptosis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
filopodium tip	IDA	24305805
lateral plasma membrane	IDA	20473291
apical plasma membrane	IDA	20016102
neuronal cell body	IDA	18986540
plasma membrane	IBA IDA ISO TAS	15035989 19966784 20016102

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

presynaptic active zone membrane

lateral plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

filopodium tip

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16687519 18606138
Wnt-protein binding	IBA IEA ISO
PDZ domain binding	IEA ISO
G protein-coupled receptor activity	IEA
Wnt receptor activity	IBA IMP	21106844

GO Hierarchy

molecular function

binding [inference]

protein binding

Wnt-protein binding

protein domain specific binding [inference]

PDZ domain binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

frizzled-3

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Wnt receptor activity
Wnt-protein binding
canonical Wnt signaling pathway
cell surface receptor signaling pathway
non-canonical Wnt signaling pathway

Displaying **all 6** entries
InterPro
Frizzled 3, cysteine-rich domain
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1928	Williams-Beuren syndrome	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **110** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7976		HGNC:4041	HUMAN93214
Caenorhabditis elegans	172856		WB:WBGene00003397
Rattus norvegicus	266715	10116_1:004648	RGD:628814	RATNO09985
Bos taurus	445419			BOVIN34180
Pan troglodytes	472726			PANTR42270
Canis lupus familiaris	486093			CANLF09952
Danio rerio	565921		ZFIN:ZDB-GENE-990415-225
Danio rerio	567746		ZFIN:ZDB-GENE-070122-1
Macaca mulatta	713839			MACMU44497
Ovis aries	780482			SHEEP09224

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024