GlyCosmos Portal

Submissions

frizzled class receptor 9

Summary

Gene Symbol

Fzd9

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14371

PubChem

14371

Alliance of Genome Resources

MGI:1313278

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9R216

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

1

2

3

4

5

6

Next ›

Last »
GO Term	Evidence Code	PMID
ossification	IMP	21402791
release of cytochrome c from mitochondria	ISS
G protein-coupled receptor signaling pathway	IEA
neuroblast proliferation	IMP	15930120
learning or memory	IMP	15930120

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

apoptotic mitochondrial changes [inference]

release of cytochrome c from mitochondria

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

postsynapse organization

multicellular organismal process [inference]

ossification

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

bone regeneration

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

bone regeneration

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering

negative regulation of skeletal muscle acetylcholine-gated channel clustering

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of protein localization [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of membrane depolarization [inference]

negative regulation of mitochondrial depolarization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of mitochondrial depolarization [inference]

negative regulation of mitochondrial depolarization

negative regulation of membrane depolarization [inference]

negative regulation of mitochondrial depolarization

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

regulation of neural precursor cell proliferation [inference]

positive regulation of neural precursor cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of protein localization [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrion organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cell cycle

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of skeletal muscle acetylcholine-gated channel clustering

negative regulation of skeletal muscle acetylcholine-gated channel clustering

negative regulation of protein localization to membrane [inference]

negative regulation of receptor clustering [inference]

negative regulation of skeletal muscle acetylcholine-gated channel clustering

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of membrane depolarization [inference]

regulation of mitochondrial depolarization [inference]

negative regulation of mitochondrial depolarization

negative regulation of membrane depolarization [inference]

negative regulation of mitochondrial depolarization

regulation of mitochondrial membrane potential [inference]

regulation of mitochondrial depolarization [inference]

negative regulation of mitochondrial depolarization

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular space	IBA
cytoplasm	ISO
endoplasmic reticulum membrane	ISS
Golgi apparatus	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

filopodium membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
Wnt-protein binding	ISO
Wnt-protein binding	IBA
Wnt-protein binding	IEA
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

Wnt-protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Frizzled

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Wnt receptor activity
Wnt-protein binding
canonical Wnt signaling pathway
cell surface receptor signaling pathway
non-canonical Wnt signaling pathway

Displaying **all 5** entries
InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1928	Williams-Beuren syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	7855	WB:WBGene00000478
Caenorhabditis elegans	8325	WB:WBGene00000478
Homo sapiens	8326	Xenbase:XB-GENE-478317	HUMAN89245
Caenorhabditis elegans	11211	WB:WBGene00000478
Caenorhabditis elegans	14362	WB:WBGene00000478
Caenorhabditis elegans	14367	WB:WBGene00000478
Caenorhabditis elegans	14370	WB:WBGene00000478
Xenopus tropicalis	14371	Xenbase:XB-GENE-478317
Xenopus tropicalis	31023	Xenbase:XB-GENE-478317
Caenorhabditis elegans	40090	WB:WBGene00000478

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements