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glial fibrillary acidic protein

Summary

Gene Symbol

Gfap

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14580

PubChem

14580

Alliance of Genome Resources

MGI:95697

Annotation

Keyword

Alternative splicing
Citrullination
Coiled coil
Cytoplasm
Direct protein sequencing
Intermediate filament
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P03995

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IMP	15135219
gene expression	IMP	15135219
positive regulation of Schwann cell proliferation	IMP	16988027
negative regulation of neuron projection development	IMP	11487638
negative regulation of neuron projection development	IGI	11487638

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell population proliferation [inference]

glial cell proliferation [inference]

Schwann cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

intermediate filament-based process

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

glial cell development [inference]

astrocyte development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection regeneration

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

supramolecular fiber organization [inference]

intermediate filament organization

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration

cell development [inference]

glial cell development [inference]

astrocyte development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

glial cell development [inference]

astrocyte development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

D-aspartate transport [inference]

D-aspartate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transport [inference]

D-aspartate import across plasma membrane

protein transport [inference]

intracellular protein transport

import into cell [inference]

amino acid import across plasma membrane [inference]

D-aspartate import across plasma membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of chaperone-mediated autophagy

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of transport [inference]

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of chaperone-mediated autophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of glial cell proliferation [inference]

regulation of Schwann cell proliferation [inference]

positive regulation of Schwann cell proliferation

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell proliferation

positive regulation of Schwann cell proliferation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO	12355421
cytoplasm	IDA	11064363 11834298 12074840 15965470 18076286 24582971
cytoplasm	IBA
cytoskeleton	IDA	29350434
intermediate filament	IDA	11487638 12533615 12878680 15656993 9364068

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection

plasma membrane bounded cell projection [inference]

glial cell projection

astrocyte projection

astrocyte end-foot

myelin sheath

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton

cell body

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of lysosomal membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
integrin binding	ISO
structural constituent of cytoskeleton	ISO
structural constituent of cytoskeleton	IMP	12177195
structural constituent of cytoskeleton	IBA
protein binding	IPI	12403814 17356066 20797626

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

kinase binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

internexin neuronal intermediate filament protein, alpha a

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intermediate filament organization
structural constituent of cytoskeleton

Displaying **all 3** entries
InterPro
Intermediate filament head, DNA-binding domain
Intermediate filament protein, conserved site
Intermediate filament, rod domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:4252	Alexander disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 93 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	1674	WB:WBGene00002058
Homo sapiens	2670	ZFIN:ZDB-GENE-990914-3	HUMAN34289
Caenorhabditis elegans	3848	WB:WBGene00002055
Caenorhabditis elegans	3849	WB:WBGene00002055
Caenorhabditis elegans	3852	WB:WBGene00002055
Caenorhabditis elegans	3855	WB:WBGene00002058
Caenorhabditis elegans	3856	WB:WBGene00002058
Caenorhabditis elegans	3858	WB:WBGene00002055
Caenorhabditis elegans	3872	WB:WBGene00002058
Caenorhabditis elegans	5630	WB:WBGene00002058

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements