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glial cell line derived neurotrophic factor family receptor alpha 2

Summary

Gene Symbol

Gfra2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14586

PubChem

14586

Alliance of Genome Resources

MGI:1195462

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
GPI-anchor
Glycoprotein
Receptor
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UET6
O08842	GDNF receptor beta Neurturin receptor alpha TGF-beta-related neurotrophic factor receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase signaling pathway	IGI	9576965
nervous system development	IMP	11069590
nervous system development	IBA
negative regulation of protein autophosphorylation	ISO
glial cell-derived neurotrophic factor receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

glial cell-derived neurotrophic factor receptor signaling pathway

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

glial cell-derived neurotrophic factor receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

regulation of protein autophosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein autophosphorylation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
external side of plasma membrane	IBA
receptor complex	IBA
side of membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glial cell-derived neurotrophic factor receptor activity	ISS
glial cell-derived neurotrophic factor receptor activity	ISO
glial cell-derived neurotrophic factor receptor activity	IBA
signaling receptor activity
heparan sulfate binding	ISS

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparan sulfate binding

sulfur compound binding [inference]

heparan sulfate binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

glial cell-derived neurotrophic factor receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

glial cell-derived neurotrophic factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDNF receptor alpha-2

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
glial cell-derived neurotrophic factor receptor activity
nervous system development

Displaying **all 4** entries
InterPro
GDNF receptor alpha
GDNF/GAS1
Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Glial cell line-derived neurotrophic factor receptor

Ortholog

Displaying entries **11 - 20** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ornithorhynchus anatinus	100074183		ORNAN22295
Xenopus tropicalis	100127717	Xenbase:XB-GENE-982254
Pongo abelii	100171804		PONAB34011
Pongo abelii	100189713		PONAB34011
Taeniopygia guttata	100224696		TAEGU13274
Callithrix jacchus	100402519		CALJA09801
Ailuropoda melanoleuca	100475044		AILME17302
Loxodonta africana	100676333		LOXAF12168
Cavia porcellus	100727079		CAVPO00817
Cricetulus griseus	100763728		CRIGR01622