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glial cell line derived neurotrophic factor family receptor alpha 3

Summary

Gene Symbol

Gfra3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14587

PubChem

14587

Alliance of Genome Resources

MGI:1201403

Annotation

Keyword

Cell membrane
Disulfide bond
GPI-anchor
Receptor
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O35118

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
neuron migration	IMP	10482239
transmembrane receptor protein tyrosine kinase signaling pathway	TAS	10331972
nervous system development	IBA
axon guidance	IMP	10482239 12160745
glial cell-derived neurotrophic factor receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

glial cell-derived neurotrophic factor receptor signaling pathway

cellular developmental process [inference]

cell development [inference]

neuron development

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development

system development [inference]

cellular developmental process [inference]

cell development [inference]

neuron development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

glial cell-derived neurotrophic factor receptor signaling pathway

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GO Term	Evidence Code	PMID
cytosol	ISO
cytosol	IEA
plasma membrane	ISO
external side of plasma membrane	IDA	9452475
external side of plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
signaling receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

glial cell-derived neurotrophic factor receptor activity

axon guidance receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

glial cell-derived neurotrophic factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDNF receptor alpha-3

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
nervous system development

Displaying **all 3** entries
InterPro
GDNF receptor alpha
GDNF/GAS1
Glial cell line-derived neurotrophic factor receptor

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2676	Xenbase:XB-GENE-988962	HUMAN80961
Xenopus tropicalis	14587	Xenbase:XB-GENE-988962
Drosophila melanogaster	66023	FB:FBgn0262869
Rattus norvegicus	84422		RATNO13967
Xenopus tropicalis	177049	Xenbase:XB-GENE-988962
Drosophila melanogaster	389400	FB:FBgn0262869
Drosophila melanogaster	404194	FB:FBgn0262869
Pan troglodytes	462093		PANTR36257
Drosophila melanogaster	501023	FB:FBgn0262869
Bos taurus	540009		BOVIN33511