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gamma-glutamyl hydrolase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14590

PubChem

14590

Alliance of Genome Resources

MGI:1329035

Annotation

Keyword

Alternative splicing
Glycoprotein
Hydrolase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z0L8	Conjugase FGPH Folylpolyglutamate hydrolase GH Gamma-Glu-x carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to xenobiotic stimulus	ISO
response to zinc ion	ISO
response to insulin	ISO
response to ethanol	ISO
tetrahydrofolylpolyglutamate metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolylpolyglutamate metabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	HDA	24006456
lysosome	TAS	9756990
vacuole	IBA
melanosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptidase activity	ISS	9756990
gamma-glutamyl-peptidase activity	ISS
gamma-glutamyl-peptidase activity	ISO
gamma-glutamyl-peptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

cysteine-type peptidase activity [inference]

gamma-glutamyl-peptidase activity

omega peptidase activity [inference]

gamma-glutamyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

cysteine-type peptidase activity [inference]

gamma-glutamyl-peptidase activity

omega peptidase activity [inference]

gamma-glutamyl-peptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Gamma-glutamyl hydrolase A

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
gamma-glutamyl-peptidase activity
hydrolase activity
omega peptidase activity
tetrahydrofolylpolyglutamate metabolic process

Displaying **all 3** entries
InterPro
Class I glutamine amidotransferase-like
Peptidase C26, gamma-glutamyl hydrolase
Peptidase C26

Rhea

RHEA:56784

H₂O

L-glutamate + (6S)-5,6,7,8-tetrahydrofolate

Enzyme

3.4.19.9

PMID

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8836	Xenbase:XB-GENE-944415	HUMAN94027
Xenopus tropicalis	14590	Xenbase:XB-GENE-944415
Rattus norvegicus	25455	Xenbase:XB-GENE-944415	RATNO34944
Danio rerio	406624		DANRE40159
Pan troglodytes	464204		PANTR42654
Bos taurus	525303		BOVIN05885
Macaca mulatta	700747		MACMU44263
Monodelphis domestica	100029624		MONDO19788
Ornithorhynchus anatinus	100082379		ORNAN24045
Taeniopygia guttata	100220150		TAEGU18608

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OrthoDB (Group)

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Acknowledgements