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gamma-glutamyltransferase 1

Summary

Gene Symbol

Ggt1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14598

PubChem

14598

Alliance of Genome Resources

MGI:95706

Annotation

Keyword

Acyltransferase
Cell membrane
Disulfide bond
Glutathione biosynthesis
Glycoprotein
Hydrolase
Protease
Reference proteome
Signal-anchor
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4FK56	Gamma-glutamyltransferase Gamma-glutamyltranspeptidase
Q60928	Gamma-glutamyltransferase 1 Gamma-glutamyltranspeptidase 1 Leukotriene-C4 hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
hepatoblast differentiation	IEA
hepatocyte differentiation	IEA
glutathione biosynthetic process	IMP	12468440
liver regeneration	IEA
cellular response to oxidative stress	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

glutamate metabolic process

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

glutathione catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

glutathione metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

organic substance catabolic process [inference]

glutathione catabolic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

serine family amino acid metabolic process [inference]

cysteine metabolic process [inference]

cysteine biosynthetic process

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cysteine metabolic process [inference]

cysteine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

cysteine biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

stem cell differentiation [inference]

hepatoblast differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

stem cell differentiation [inference]

hepatoblast differentiation

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to cytokine [inference]

response to tumor necrosis factor

response to alcohol

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane
plasma membrane	IBA ISO ISS TAS	8566783
vesicle	IDA	23863468
endoplasmic reticulum	ISO
extracellular space	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
aminoacyltransferase activity	ISO
leukotriene-C(4) hydrolase	IEA ISO
glutathione hydrolase activity	IBA ISO ISS	20622017
peptidyltransferase activity	ISO
leukotriene C4 gamma-glutamyl transferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a protein [inference]

peptidyltransferase activity

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

peptidyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Gamma-glutamyltranspeptidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
glutathione catabolic process
glutathione hydrolase activity
hydrolase activity
transferase activity

Displaying **all 4** entries
InterPro
Gamma-glutamyltranspeptidase, large subunit, C-terminal domain
Gamma-glutamyltranspeptidase, small subunit
Gamma-glutamyltranspeptidase
Nucleophile aminohydrolases, N-terminal

Disease

Disease Ontology

Displaying entries **11 - 14** of 14 in total

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DO ID	Disease Name	Source
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2678		HGNC:4250	HUMAN59643
Homo sapiens	2679		HGNC:4252
Drosophila melanogaster	32672		FB:FBgn0030796
Drosophila melanogaster	32839		FB:FBgn0030932
Homo sapiens	91227		HGNC:18596
Homo sapiens	92086		HGNC:16437
Rattus norvegicus	116568	10116_1:005264	RGD:2683	RATNO22295
Caenorhabditis elegans	171619		WB:WBGene00016906
Caenorhabditis elegans	178453		WB:WBGene00012416
Caenorhabditis elegans	179271		WB:WBGene00019204

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements